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首页> 外文期刊>RSC Advances >Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate
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Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate

机译：丙二酸二乙酯中各种卤代（手性）乙酸的合成路线

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摘要

Chiral halomethane is the smallest stable molecule with a single asymmetric C-atom and halogenated acetic acids often serve as precursors. We focus on a synthetic route to synthesise chiral halogenated acetic acids with F, Cl, Br, and H/D isotopic substitution at the α-C-atom starting from diethyl malonate. This reactant is easily available, cheap and allows the obtainment of target acids in a few reaction steps with great versatility. Among all of the possible fully halogenated acetic acids (more than one hundred, which are, in principle, accessible by this route), there are only a small number of chiral halogenated acetic acids, which have been synthesized following the devised synthetic route.
机译：手性卤代甲烷是具有单个不对称C原子的最小稳定分子，卤代乙酸通常用作前体。我们专注于从丙二酸二乙酯开始在α-C原子上合成具有F，Cl，Br和H / D同位素取代的手性卤代乙酸的合成途径。该反应物容易获得，便宜并且允许在几个反应步骤中以极大的多功能性获得目标酸。在所有可能的全卤代乙酸中（原则上可通过该途径获得一百多种），只有少量的手性卤代乙酸是按照设计的合成途径合成的。

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