Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate

Mazenauer Manuel R.; Manov Stole; Galati Vanessa M.; Kappeler Philipp; Stohner Jurgen

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Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate

机译：来自丙二酸二乙酯的各种卤化（手性）乙酸的合成途径

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Chiral halomethane is the smallest stable molecule with a single asymmetric C-atom and halogenated acetic acids often serve as precursors. We focus on a synthetic route to synthesise chiral halogenated acetic acids with F, Cl, Br, and H/D isotopic substitution at the alpha-C-atom starting from diethyl malonate. This reactant is easily available, cheap and allows the obtainment of target acids in a few reaction steps with great versatility. Among all of the possible fully halogenated acetic acids (more than one hundred, which are, in principle, accessible by this route), there are only a small number of chiral halogenated acetic acids, which have been synthesized following the devised synthetic route.

机译：手性卤代甲烷是具有单个不对称C-原子的最小稳定分子，卤代乙酸通常用作前体。我们专注于合成途径以在丙二酸二乙酯开始的α-C-原子处用F，Cl，Br和H / d同位取代合成手性卤代乙酸。这种反应物易于使用，便宜，并允许在几个反应步骤中获得靶酸，其具有极大的通用性。在所有可能的完全卤化的乙酸（一百多于一百个，原则上是通过该途径可进入），只有少量的手性卤代乙酸，其在设计的合成途径之后已经合成。

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《RSC Advances》 |2017年第87期|共7页
作者
Mazenauer Manuel R.; Manov Stole; Galati Vanessa M.; Kappeler Philipp; Stohner Jurgen;
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Zurich Univ Appl Sci Inst Chem &

Biotechnol Einsiedlerstr 31 CH-8820 Wadenswil Switzerland;

Zurich Univ Appl Sci Inst Chem &

Biotechnol Einsiedlerstr 31 CH-8820 Wadenswil Switzerland;

Zurich Univ Appl Sci Inst Chem &

Biotechnol Einsiedlerstr 31 CH-8820 Wadenswil Switzerland;

Zurich Univ Appl Sci Inst Chem &

Biotechnol Einsiedlerstr 31 CH-8820 Wadenswil Switzerland;

Zurich Univ Appl Sci Inst Chem &

Biotechnol Einsiedlerstr 31 CH-8820 Wadenswil Switzerland;

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正文语种 eng
中图分类化学;
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1. Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate (vol 7, pg 55434, 2017) [J] . Mazenauer Manuel R., Manov Stole, Galati Vanessa M., RSC Advances . 2018,第6期

机译：来自丙二酸二乙基亚乙酯（Vol 7，PG 55434,2017）的各种卤化（手性）乙酸的合成途径
2. Correction: Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate [J] . Manuel R. Mazenauer, Stole Manov, Vanessa M. Galati, RSC Advances . 2018,第6期

机译：校正：丙二酸二乙酯中各种卤代（手性）乙酸的合成路线
3. Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate [J] . Mazenauer Manuel R., Manov Stole, Galati Vanessa M., RSC Advances . 2017,第87期

机译：来自丙二酸二乙酯的各种卤化（手性）乙酸的合成途径
4. Bronsted Acidic Ionic Liquids Supported Synthesis of Diethyl Malonate and Its Characterization [C] . International symposium on fine chemistry and functional polymers . 2008

机译：富棱镜酸性离子液体负载合成丙二酸二乙酯及其表征
5. Amino acids as chiral templates in the stereoselective syntheses of bioactive compounds: I. Stereoselective routes to 2,3-disubstituted piperidines. II. Synthetic studies on polyoxin J. [D] . Liang, Ningning. 2006

机译：氨基酸作为生物活性化合物立体选择性合成中的手性模板：I.立体选择性合成2,3-二取代哌啶的途径。二。多聚毒素J的合成研究。
6. Targeted Metabolomic Assessment of the Sub-Lethal Toxicity of Halogenated Acetic Acids (HAAs) to [O] . Lisa M. Labine, Myrna J. Simpson 2021

机译：针对卤代乙酸（HAAs）的亚致死毒性的目标代谢评估
7. Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate [O] . Manuel R. Mazenauer, Stole Manov, Vanessa M. Galati, 2017

机译：来自丙二酸二乙酯的各种卤化（手性）乙酸的合成途径

Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate

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