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首页> 外文期刊>RSC Advances >Preparation of a colon-specific sustained-release capsule with curcumin-loaded SMEDDS alginate beads
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Preparation of a colon-specific sustained-release capsule with curcumin-loaded SMEDDS alginate beads

机译：载有姜黄素的SMEDDS海藻酸盐微珠的结肠特异性缓释胶囊的制备

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A colon-specific capsule with alginate beads containing a self-microemulsifying drug delivery system (SMEDDS) was developed and evaluated. The SMEDDS technique was used to improve the solubility of curcumin (Cur). After encapsulating the Cur-loaded SMEDDS, the alginate beads were placed inside an impermeable capsule body. A konjac glucomannan/lactose/hydroxypropyl methylcellulose (KG/Lac/HPMC) plug tablet was then prepared and placed in the mouth of the capsule. The capsule demonstrated a pulsatile drug-release profile with a specific lag time and subsequent sustained-release phase. The lag time was modified by changing the type of HPMC and the ratio of KG/Lac/HPMC. In addition, 0.5% β-mannase solution and 5% rat cecal solution were used to simulate the colon fluid, significantly decreasing the lag time of the capsule. The results show that the capsule has potential for use in colon-specific drug delivery and exhibits a sustained-release characteristic.
机译：开发并评估了带有藻酸盐珠的结肠特异胶囊，其中含有自微乳化药物递送系统（SMEDDS）。 SMEDDS技术用于提高姜黄素（Cur）的溶解度。包封Cur加载的SMEDDS后，将藻酸盐珠粒置于不可渗透的胶囊体内。然后制备魔芋葡甘露聚糖/乳糖/羟丙基甲基纤维素（KG / Lac / HPMC）塞片并将其置于胶囊的口中。该胶囊显示出脉动性药物释放曲线，具有特定的滞后时间和随后的持续释放阶段。通过更改HPMC的类型和KG / Lac / HPMC的比例来修改滞后时间。此外，使用0.5％β-甘露聚糖溶液和5％大鼠盲肠溶液模拟结肠液，显着减少了胶囊的滞后时间。结果表明该胶囊具有用于结肠特异性药物递送的潜力，并显示出持续释放的特性。

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