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Effects of naturally occurring flavonoids on ferroportin expression in the spleen in iron deficiency anemia in vivo

机译：天然黄酮对缺铁性贫血脾中铁转运蛋白表达的影响

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Anemia due to iron deficiency is one of the unsolved issues around the globe for which oral iron supplementation is the common treatment. However, the consumption of complex diets plays an important role in modulating iron homeostasis. In this study, we aimed to examine the interaction of ubiquitous polyphenol, quercetin and related flavonoids with iron supplements in an animal model of iron deficiency anemia (IDA). Female weanling Sprague Dawley rats were kept on a low iron diet for 20 days to induce iron deficiency anemia followed with 50 mg kg?1 ferrous sulfate (FS) supplement combined in equal ratio with quercetin (Que), quercetagetin (Qtg), and patuletin (Pat) for 30 days. Besides evaluation of basic hematological parameters, we mainly investigated changes in expression of splenic ferroportin by immunohistochemistry. Our data indicate that each polyphenol shows different outcomes and regulates iron variably which might result from differences in their structures. However, the combination of various flavonoids and iron significantly increases hemoglobin, serum iron, splenic iron stores and ferroportin as compared to a model group. The QtgFS combination was found to show more control over blood parameters. Splenic iron stores achieved with the QueFS and QtgFS combinations were found to increase similarly to with FS alone. Ferroportin expression was increased as in the order QueFS < QtgFS < PatFS where quercetin showed comparatively strict control over ferroportin regulation when administered with FS compared to the other flavonoid iron combinations. This variation in regulation needs to be explained further. To conclude, different polyphenols regulate ferroportin expression and ultimately iron homeostasis differently and should be further evaluated for their effect on iron regulation.
机译：缺铁引起的贫血是全球尚未解决的问题之一，口服补铁是常见的治疗方法。然而，复杂饮食的摄入在调节铁稳态中起着重要作用。在这项研究中，我们旨在检查铁缺乏性贫血（IDA）动物模型中普遍存在的多酚，槲皮素和相关类黄酮与铁补充剂的相互作用。将雌性断奶的Sprague Dawley大鼠保持低铁饮食20天，以诱发缺铁性贫血，然后以等量的方式结合50 mg kg ？1 硫酸亚铁（FS）补充剂与槲皮素（Que），槲皮素（Qtg）和帕图汀（Pat）混合30天。除了评估基本的血液学参数外，我们还主要通过免疫组织化学研究了脾铁转运蛋白表达的变化。我们的数据表明，每种多酚均显示出不同的结果，并可能因其结构差异而可变地调节铁。但是，与模型组相比，各种类黄酮和铁的组合显着增加了血红蛋白，血清铁，脾铁储备和铁转运蛋白。发现QtgFS组合显示出对血液参数的更多控制。发现与QueFS和QtgFS组合使用可使脾铁储量增加，与单独使用FS相似。递铁转运蛋白的表达按照QueFS

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