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首页> 外文期刊>RSC Advances >Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression
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Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression

机译：蚕粪提取物通过抑制铁调素表达并促进铁调节蛋白表达改善铁缺乏性贫血

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Iron deficiency anemia (IDA) is a global public health problem that imposes negative effects on human quality of life, especially in pregnant women and children. Silkworm feces extract (SFE) has been used for improving renal anemia of maintenance hemodialysis patients. In this study, we aimed to explore the preventive efficacy of SFE toward iron deficiency anemia in rats and clarify the underlying mechanisms. Our study demonstrated that SFE treatment improved hematological parameters, decreased TIBC, increased serum iron, transferrin saturation, liver iron and spleen iron of IDA rats. Western blot analysis showed that SFE upregulated iron-regulatory proteins (IRPs) expression and downregulated ferritin expression in livers. Furthermore, SFE inhibited hepcidin expression and increased ferroportin1 expression by blocking JAK2/STAT3, BMP6/SMAD, and HFE/TfR2 pathways. And SFE also attenuated hepcidin expression induced by IL-6 and BMP6 in HepG2 cells. These findings suggested that SFE may be an efficient oral iron supplement to ameliorate iron deficiency anemia.
机译：缺铁性贫血（IDA）是一个全球性的公共卫生问题，对人类的生活质量，尤其是孕妇和儿童，造成不良影响。蚕粪提取物（SFE）已用于改善维持性血液透析患者的肾脏贫血。在这项研究中，我们旨在探讨SFE对大鼠缺铁性贫血的预防功效，并阐明其潜在机制。我们的研究表明，SFE治疗可改善IDA大鼠的血液学参数，降低TIBC，增加血清铁，转铁蛋白饱和度，肝铁和脾铁。蛋白质印迹分析表明，SFE在肝脏中上调铁调节蛋白（IRP）的表达而下调铁蛋白的表达。此外，SFE通过阻止JAK2 / STAT3，BMP6 / SMAD和HFE / TfR2途径抑制了铁调素表达并增加了ferroportin1表达。 SFE还减弱了HepG2细胞中IL-6和BMP6诱导的铁调素表达。这些发现表明，SFE可能是缓解铁缺乏性贫血的有效口服铁补充剂。

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