• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression
【24h】

Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression

机译：蚕粪便提取物通过抑制肝素的表达和促进铁调节蛋白表达来改善缺铁性贫血

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Iron deficiency anemia (IDA) is a global public health problem that imposes negative effects on human quality of life, especially in pregnant women and children. Silkworm feces extract (SFE) has been used for improving renal anemia of maintenance hemodialysis patients. In this study, we aimed to explore the preventive efficacy of SFE toward iron deficiency anemia in rats and clarify the underlying mechanisms. Our study demonstrated that SFE treatment improved hematological parameters, decreased TIBC, increased serum iron, transferrin saturation, liver iron and spleen iron of IDA rats. Western blot analysis showed that SFE upregulated iron-regulatory proteins (IRPs) expression and downregulated ferritin expression in livers. Furthermore, SFE inhibited hepcidin expression and increased ferroportin1 expression by blocking JAK2/STAT3, BMP6/SMAD, and HFE/TfR2 pathways. And SFE also attenuated hepcidin expression induced by IL-6 and BMP6 in HepG2 cells. These findings suggested that SFE may be an efficient oral iron supplement to ameliorate iron deficiency anemia.
机译：缺铁性贫血（IDA）是一个全球性的公共卫生问题，对人类生活质量产生负面影响，特别是在孕妇和儿童中。蚕粪便提取物（SFE）已被用于改善维持血液透析患者的肾贫血。在这项研究中，我们旨在探讨SFE在大鼠中对缺铁性贫血的预防效果，并阐明潜在机制。我们的研究表明，SFE治疗改善了血液学参数，降低TIBC，血清铁，转铁素饱和，肝脏铁和IDA大鼠的脾脏。 Western印迹分析表明，SFE上调的铁调节蛋白（IRP）表达和下调的肝素中的铁蛋白表达。此外，通过阻断JAK2 / Stat3，BMP6 / Smad和HFE / TFR2途径，SFE抑制肝素表达和冰乳蛋白1表达增加。和SFE还减毒IL-6和BMP6在HepG2细胞中诱导的肝素表达。这些发现表明，SFE可以是有效的口服铁补充剂，以改善缺铁性贫血。

著录项

  • 来源
    《RSC Advances》 |2017年第79期|共11页
  • 作者

    Huang Xiao; Wu Jun; Li Qiang; Gu Saisai; Chen Zehong; Wang Kaiping;

  • 作者单位

    Huazhong Univ Sci &

    Technol Union Hosp Tongji Med Coll 1277 Jiefang Rd Wuhan 430022 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Hubei Key Lab Nat Med Chem &

    Resource Evaluat Tongji Med Coll 13 Hangkong Rd Wuhan 430022 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Union Hosp Tongji Med Coll 1277 Jiefang Rd Wuhan 430022 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Hubei Key Lab Nat Med Chem &

    Resource Evaluat Tongji Med Coll 13 Hangkong Rd Wuhan 430022 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Union Hosp Tongji Med Coll 1277 Jiefang Rd Wuhan 430022 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Hubei Key Lab Nat Med Chem &

    Resource Evaluat Tongji Med Coll 13 Hangkong Rd Wuhan 430022 Hubei Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号