Optimized PAMAM coated magnetic nanoparticles for simultaneous hyperthermic treatment and contrast enhanced MRI diagnosis

A. Boni; A.?M. Basini; L. Capolupo; C. Innocenti; M. Corti; M. Cobianchi; F. Orsini; A. Guerrini; C. Sangregorio; A. Lascialfari

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Optimized PAMAM coated magnetic nanoparticles for simultaneous hyperthermic treatment and contrast enhanced MRI diagnosis

机译：优化的PAMAM涂层磁性纳米颗粒可同时进行高温治疗和造影剂增强MRI诊断

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We report the synthesis and characterization of multi-functional monodisperse superparamagnetic Magnetic NanoParticles, MNPs, able to act as contrast agents for magnetic resonance and Magnetic Fluid Hyperthermia (MFH) mediators. The investigated samples are constituted of a magnetic core of magnetite and a biocompatible PAMAM coating. We studied two samples with the same magnetic volume but different shape, i.e. spherical and faceted. Despite the relatively large size (MNPs of 20 nm diameter) that generally leads to particles' aggregation and instability, the resulting samples were very stable. For faceted MNPs, the efficiency in contrasting Magnetic Resonance images, i.e. the nuclear transverse 1H NMR relaxivity r₂, reached values of about 250/300 mM?1 s?1 at clinical frequencies f > 5 MHz, i.e. 2.5/3 times higher than the commercial compound Endorem, while the Specific Absorption Rate at H_ac ～ 10 kA m?1 and frequency f < 300 kHz (i.e. within the physiological limits) reaches 900 W g?1, suggesting this system as a potentially useful mediator for MFH. The experimental data strongly indicate the new synthesized MNP systems as good candidates for theranostic applications.

机译：我们报告了合成和表征的多功能单分散超顺磁磁性纳米颗粒，MNPs，能够充当磁共振和磁流体热疗（MFH）介体的造影剂。研究的样品由磁铁矿的磁芯和生物相容的PAMAM涂层组成。我们研究了两个具有相同磁体积但形状不同的样品，即球形和多面的。尽管相对较大的尺寸（直径为20 nm的MNP）通常会导致颗粒聚集和不稳定，但所得样品非常稳定。对于多面MNP，对比磁共振图像（ ie ）核横 1 H NMR弛豫度 r < small> _{2 ，达到约250/300 mM ？1 s ？1 在临床频率 f ie 比市售化合物Endorem高2.5 / 3倍，而在 H下的比吸收率 _{ac 〜10 kA m ？1 和频率 f < 300 kHz（在生理范围内为 ie ）达到900 W g ？1 ，这表明该系统可能是MFH的有用介体。实验数据强烈表明，新合成的MNP系统是治疗学应用的良好候选者。}} 展开▼

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《RSC Advances》 |2017年第70期|共8页

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A. Boni; A.?M. Basini; L. Capolupo; C. Innocenti; M. Corti; M. Cobianchi; F. Orsini; A. Guerrini; C. Sangregorio; A. Lascialfari;
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1. Optimized PAMAM coated magnetic nanoparticles for simultaneous hyperthermic treatment and contrast enhanced MRI diagnosis [J] . Boni A., Basini A. M., Capolupo L., RSC Advances . 2017,第70期

机译：优化的PAMAM涂层磁性纳米粒子，用于同时热疗和对比增强MRI诊断

2. Optimized PAMAM coated magnetic nanoparticles for simultaneous hyperthermic treatment and contrast enhanced MRI diagnosis [J] . A. Boni, A.?M. Basini, L. Capolupo, RSC Advances . 2017,第70期

机译：优化的PAMAM涂层磁性纳米颗粒可同时进行高温治疗和造影剂增强MRI诊断

3. Critical Enhancements of MRI Contrast and Hyperthermic Effects by Dopant-Controlled Magnetic Nanoparticles [J] . Jung-tak Jang, Hyunsoo Nah, Jae-Hyun Lee Angewandte Chemie . 2009,第7期

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Optimized PAMAM coated magnetic nanoparticles for simultaneous hyperthermic treatment and contrast enhanced MRI diagnosis

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