Fast screening of whole blood samples for early detection and monitoring of thyroid diseases

Raluca-Ioana Stefan-van Staden; Grigorina Mitrofan

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Fast screening of whole blood samples for early detection and monitoring of thyroid diseases

机译：快速筛选全血样本，以及早发现和监测甲状腺疾病

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This paper described a fast and reliable method for the screening of whole blood for TSH, L-T₄, L-T₃ and D-T₄ using stochastic sensors. The main advantage of this method is the possibility of tracing the precise diagnosis of thyroid dysfunction from a single whole blood sample by multianalyte screening in one run, with low cost. Six stochastic microsensors based on mixtures between inulins: Frutafruit TEX (TEX) and inulin Inutec (IN), and ionic liquids: L-phenylalanine-tert-butyl-ester-lactate (L-PheC₄-Lac), L-alanine-tert-butyl-ester-L-lactate (L-AlaC₄-Lac) and L-alanine-tert-butyl-ester-nitrate (L-AlaC₄-NO₃), physically immobilized in a diamond paste matrix were designed and used for the screening tests. The tests were reliable for the assay of TSH, L-T₄, L-T₃ and D-T₄ in whole blood samples, with recoveries higher than 98.00% with RSD values lower than 1.00% being recorded.

机译：本文描述了一种快速可靠的全血筛查TSH，LT _{4 ，LT _{3 的方法和DT _{4 使用随机传感器。这种方法的主要优点是可以通过一次运行就可以通过多分析物筛查从单个全血样本中准确诊断出甲状腺功能障碍，且成本低廉。基于菊粉之间的混合物的六种随机微传感器：Frutafruit TEX（TEX）和菊粉Inutec（IN），以及离子液体： L -苯丙氨酸-叔-丁基酯-乳酸酯（ L -PheC _{4 -Lac）， L -丙氨酸-叔-丁酯- L -乳酸酯（ L -AlaC _{4 -Lac）和 L -丙氨酸-叔-硝酸丁酯（ L -AlaC _{4 -NO 设计了物理固定在金刚石浆料基质中的_{3 ，并将其用于筛选测试。这些测试对TSH，LT _{4 ，LT _{3 和DT 4 ，记录的回收率高于98.00％，RSD值低于1.00％。}}}}}}}}} 展开▼

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《RSC Advances》 |2017年第69期|共7页

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Raluca-Ioana Stefan-van Staden; Grigorina Mitrofan;
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中图分类化学;

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1. Fast screening of whole blood samples for early detection and monitoring of thyroid diseases [J] . Stefan-van Staden Raluca-Ioana, Mitrofan Grigorina RSC Advances . 2017,第69期

机译：快速筛选全血样品，用于早期检测和监测甲状腺疾病

2. Neonatal thyroid screening: Relationship between cord blood thyroid stimulating hormone levels and thyroid stimulating hormone in heel prick sample on 4th to 7th day-of-life [J] . Mahmood Dhahir Al-Mendalawi Indian Journal of Endocrinology and Metabolism . 2015,第1期

机译：新生儿甲状腺筛查：出生后第4至第7天脐带血针刺样品中脐血甲状腺刺激激素水平与甲状腺刺激激素之间的关系

3. Neonatal thyroid screening: Relationship between cord blood thyroid stimulating hormone levels and thyroid stimulating hormone in heel prick sample on 4th to 7th day-of-life [J] . Anju Seth, M. Rashmi, Bhanu Kiran Bhakhri, Indian Journal of Endocrinology and Metabolism . 2014,第1期

机译：新生儿甲状腺筛查：出生后第4至第7天脐带血针刺样品中脐血甲状腺刺激激素水平与甲状腺刺激激素之间的关系

4. SYNDROMIC SURVEILLANCE ON BLOOD SAMPLES OF ABORTING COWS FOR EARLY DETECTION OF (EMERGING) INFECTIOUS DISEASES USING DIFFERENT STATISTICAL METHODS [C] . H. BROUWER, C.J.M. BARTELS, L. VAN WUHCKHUISE, Meeting of the Society for Veterinary Epidemiology and Preventive Medicine . 2012

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5. The use of blood-fed mosquitoes as diagnostic tools for the detection and monitoring of infectious disease in wildlife. [D] . Leighton, Bruce J. 2005

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6. Waist Circumference Is Not Associated with Impaired Fasting Blood Glucose in a Sample of Mexican Children and Teenagers: Results from a State Screening Program [O] . Edtna Jáuregui-Ulloa, Alejandro Gaytán-González, Mayra Elizalde-Villarreal, 2021

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7. Neonatal thyroid screening: Relationship between cord blood thyroid stimulating hormone levels and thyroid stimulating hormone in heel prick sample on 4 th to 7 th day-of-life [O] . Mahmood Dhahir Al-Mendalawi 2015

机译：新生儿甲状腺筛查：脐带血促甲状腺激素水平与足跟刺样本中第4至第7天甲状腺刺激素的关系

8. Application of cabin atmosphere monitors to rapid screening of breath samples for the early detection of disease states [R] . Valentine, J. L., Bryant, P. J. 1975

机译：应用机舱气氛监测仪快速筛查呼吸样本，以便早期发现疾病状态

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7. 抗PD-L1单克隆抗体在食蟹猴全血和PBMC两种样本的受体占位方法学比较 [A] . 李利珍 . 2020

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机译：筛选个体为糖原贮积病的方法，以清除个体为庞贝氏病的方法。监测临床上个体为庞贝氏病的情况。与庞贝病相关的个体，并测定生物样品中寡糖的浓度

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机译：检测生物学样品中血液的存在的方法，以检测下消化道出血，胃肠道上段的出血。诊断疾病状况并检测生物学样品中分析物的存在。

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Fast screening of whole blood samples for early detection and monitoring of thyroid diseases

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