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首页> 外文期刊>RSC Advances >Preparation of multifunctional Fe3O4@ZnAl2O4:Eu3+@mSiO2–APTES drug-carrier for microwave controlled release of anticancer drugs
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Preparation of multifunctional Fe3O4@ZnAl2O4:Eu3+@mSiO2–APTES drug-carrier for microwave controlled release of anticancer drugs

机译：多功能Fe 3 O 4 @ZnAl 2 O 4 ：Eu 3 + @mSiO 2 –APTES药物载体用于微波控制抗癌药物的释放

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A carrier possessing simple structure and composition, but with microwave-targeted-fluorescence multifunctional properties to precisely control the delivery of the drug was prepared. Herein, we have constructed the multifunctional Fe3O4@ZnAl2O4:Eu3+@mSiO2–APTES core–shell drug-carrier via direct precipitation method and sol–gel process with surfactant-assistance approach. This carrier is a monodisperse microsphere with an average particle size of 325 nm. Fe3O4 in the core has a high saturation magnetization and provides the Fe3O4@ZnAl2O4:Eu3+@mSiO2–APTES with good drug targeting properties. The ZnAl2O4:Eu3+ interlayer has the characteristic of fluorescent luminescence and can be used to monitor the transport of drugs in the body in real time. In addition, the ZnAl2O4:Eu3+ as a dielectric loss microwave absorbing material combines with the high magnetic loss Fe3O4 to form a composite material, which improved the microwave thermal response. Over 78.2% of VP16 molecules were released under microwave trigger. In addition, mesoporous silica nanoparticles in the outer layer improve the drug loading efficiency through organic modification. The results indicated that this multifunctional drug-carrier with simple structure and composition is a potential controlled drug delivery system in cancer therapy.
机译：制备了具有简单结构和组成，但具有微波靶向荧光多功能性能以精确控制药物递送的载体。在这里，我们构造了多功能的Fe 3 O 4 @ZnAl 2 O 4 ：Eu 3 + @mSiO 2 < / sub> -APTES核-壳药物载体通过直接沉淀法和表面活性剂辅助法的溶胶-凝胶法。该载体是平均粒径为325 nm的单分散微球。铁心中的Fe 3 O 4 具有高饱和磁化强度，并提供Fe 3 O 4 @ZnAl 2 O 4 ：Eu 3 + @mSiO 2 –APTES具有良好的靶向作用。 ZnAl 2 O 4 ：Eu 3 + 中间层具有荧光发光的特性，可用于实时监测药物在体内的传输。另外，ZnAl 2 O 4 ：Eu 3 + 作为介电损耗微波吸收材料与高磁损耗Fe 3 O 4 组合在一起形成复合材料，从而改善了微波的热响应。微波触发下释放了超过78.2％的VP16分子。另外，在外层中的介孔二氧化硅纳米颗粒通过有机改性提高了药物装载效率。结果表明，这种具有简单结构和组成的多功能药物载体是癌症治疗中潜在的受控药物递送系统。

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