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首页> 外文期刊>RSC Advances >Preparation of multifunctional Fe3O4@ZnAl2O4:Eu3+@mSiO(2)-APTES drug-carrier for microwave controlled release of anticancer drugs
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Preparation of multifunctional Fe3O4@ZnAl2O4:Eu3+@mSiO(2)-APTES drug-carrier for microwave controlled release of anticancer drugs

机译：多功能Fe3O4的制备@ Znal2O4：Eu3 + @ MSIO（2） - 用于微波控制释放的抗癌药物的药物 - 载体

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摘要

A carrier possessing simple structure and composition, but with microwave-targeted-fluorescence multifunctional properties to precisely control the delivery of the drug was prepared. Herein, we have constructed the multifunctional Fe3O4@ZnAl2O4:Eu3+@mSiO(2)-APTES core-shell drug-carrier via direct precipitation method and sol-gel process with surfactant-assistance approach. This carrier is a monodisperse microsphere with an average particle size of 325 nm. Fe3O4 in the core has a high saturation magnetization and provides the Fe3O4@ZnAl2O4:Eu3+@mSiO(2)-APTES with good drug targeting properties. The ZnAl2O4:Eu3+ interlayer has the characteristic of fluorescent luminescence and can be used to monitor the transport of drugs in the body in real time. In addition, the ZnAl2O4: Eu3+ as a dielectric loss microwave absorbing material combines with the high magnetic loss Fe3O4 to form a composite material, which improved the microwave thermal response. Over 78.2% of VP16 molecules were released under microwave trigger. In addition, mesoporous silica nanoparticles in the outer layer improve the drug loading efficiency through organic modification. The results indicated that this multifunctional drug-carrier with simple structure and composition is a potential controlled drug delivery system in cancer therapy.
机译：制备具有简单结构和组合物的载体，但具有微波靶向荧光多功能性能，精确控制药物的递送。在此，我们通过直接沉淀法和具有表面活性剂 - 辅助方法的直接沉淀法和溶胶 - 凝胶工艺构建了多功能Fe 3 O 4：Eu3 + @ MSIO（2） - 核 - 壳药物 - 载体。该载体是单分散的微球，平均粒径为325nm。核心的Fe3O4具有高饱和磁化，并提供Fe3O4 @ Znal2O4：Eu3 + @ MSIO（2） - 具有良好药物靶向性质的eu3 + @ MSIO（2）。 ZNAL2O4：EU3 +中间层具有荧光发光的特征，可用于实时监测体内药物的运输。另外，Znal2O4：Eu3 +作为介电损耗微波吸收材料与高磁损失Fe3O4结合形成复合材料，其改善了微波热响应。在微波触发下释放超过78.2％的VP16分子。另外，外层中的中孔二氧化硅纳米颗粒通过有机改性改善药物负载效率。结果表明，具有简单结构和组合物的这种多功能药物载体是癌症治疗中的潜在受控药物递送系统。

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  • 来源
    《RSC Advances》 |2017年第87期|共7页
  • 作者

    Bu Yumei; Cui Bin; Zhao Weiwei; Yang Zhenfeng;

  • 作者单位

    Northwest Univ Xian Key Lab Synthet &

    Nat Funct Mol Chem Minist Educ Shaanxi Key Lab Physicoinorgan Chem Coll Chem &

    M 1 Xuefu Ave Xian 710127 Shaanxi Peoples R China;

    Northwest Univ Xian Key Lab Synthet &

    Nat Funct Mol Chem Minist Educ Shaanxi Key Lab Physicoinorgan Chem Coll Chem &

    M 1 Xuefu Ave Xian 710127 Shaanxi Peoples R China;

    Northwest Univ Xian Key Lab Synthet &

    Nat Funct Mol Chem Minist Educ Shaanxi Key Lab Physicoinorgan Chem Coll Chem &

    M 1 Xuefu Ave Xian 710127 Shaanxi Peoples R China;

    Northwest Univ Xian Key Lab Synthet &

    Nat Funct Mol Chem Minist Educ Shaanxi Key Lab Physicoinorgan Chem Coll Chem &

    M 1 Xuefu Ave Xian 710127 Shaanxi Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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