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首页> 外文期刊>RSC Advances >Dual redox-responsive PEG–PPS–cRGD self-crosslinked nanocapsules for targeted chemotherapy of squamous cell carcinoma
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Dual redox-responsive PEG–PPS–cRGD self-crosslinked nanocapsules for targeted chemotherapy of squamous cell carcinoma

机译：双重氧化还原反应性PEG-PPS-cRGD自交联纳米胶囊用于鳞癌的靶向化疗

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Polymer nanogelsanocapsules with encapsulation stability, stimuli responsiveness and tumor targeting have emerged as one of the most remarkable carriers for anticancer drug delivery. In this work, we design a multifunctional, four-armed, branched copolymer, PEG–PPS–cRGD, and use it to develop a dual redox-responsive and αvβ3 integrin-targeting nanocapsule via a simple and straightforward self-crosslinking strategy through the disulfide exchange reaction between the polymer arms. The dissolution rate studies illustrate that the PEG–PPS–cRGD nanocapsules had robust drug release profiles under both oxidation and reduction conditions. The in vitro and in vivo investigations demonstrate that the nanocapsules exhibited precise tumor targeting, outstanding antitumor effect and excellent biological safety in the treatment of squamous cell carcinoma. Therefore, this work provides a promising drug delivery platform for cancer therapy and other applications.
机译：具有封装稳定性，刺激响应性和肿瘤靶向性的聚合物纳米凝胶/纳米胶囊已成为抗癌药物递送的最显着载体之一。在这项工作中，我们设计了一种多功能的四臂支链共聚物PEG-PPS-cRGD，并用它开发了一个对氧化还原敏感的双和α v β 3 靶向整联蛋白的纳米胶囊通过通过聚合物臂之间的二硫键交换反应进行的简单直接的自交联策略。溶出度研究表明，PEG-PPS-cRGD纳米胶囊在氧化和还原条件下均具有强大的药物释放特性。 体外和体内研究表明，纳米胶囊在鳞状细胞癌的治疗中具有精确的肿瘤靶向，出色的抗肿瘤作用和极好的生物安全性。因此，这项工作为癌症治疗和其他应用提供了有希望的药物输送平台。

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