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首页> 外文期刊>RSC Advances >Evaluation of the efficacy and safety of Ganoderma lucidum mycelium-fermented liquid on gut microbiota and its impact on cardiovascular risk factors in human
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Evaluation of the efficacy and safety of Ganoderma lucidum mycelium-fermented liquid on gut microbiota and its impact on cardiovascular risk factors in human

机译：灵芝菌丝发酵液对肠道菌群的有效性和安全性及其对人心血管危险因素的影响

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摘要

Ganoderma lucidum is a Chinese traditional medicine with various bioactivities. However, the impacts of a Ganoderma lucidum mycelium-fermented liquid (GLFL), as a promising alternative product, on the gut microbes and cardiovascular risk factors have not been explored in humans to date. In this study, the composition of polysaccharides in GLFL was analyzed, and eight volunteers were fed with GLFL to investigate its influence on gut microbes and cardiovascular risk factors. High-throughput 16S rRNA gene sequencing technique was utilized to investigate the effects of GLFL on the diversity of the bacterial communities and the composition of gut microbiota. The results demonstrated that GLFL significantly altered β diversity and several phyla of gut microbiota in volunteers. Moreover, GLFL provided protection to humans by promoting the growth of probiotics, incorporating genus Lactobacillus (p < 0.05), and reducing pathogens containing genus Campylobacter and Aggregatibacter (p < 0.05); however, GLFL also had detrimental effects as it increased the population of Firmicutes/Bacteroidetes and opportunistic pathogens including genus Acinetobacter, Pseudomonas, Serratia, Stenotrophomonas, Peptococcus and S24-7 (p < 0.05) and reduced that of probiotics genus Lactococcus. Finally, we found that GLFL reduced plasma low-density lipoprotein cholesterol (LDL-c) in volunteers. This is helpful for further understanding the effect of Ganoderma lucidum or its related products on human body.
机译：灵芝是具有多种生物活性的中药。然而，迄今为止，尚未在人类中探索灵芝菌丝发酵液（GLFL）作为有前途的替代产品对肠道微生物和心血管危险因素的影响。在这项研究中，分析了GLFL中多糖的组成，并向八名志愿者喂养了GLFL，以研究其对肠道微生物和心血管危险因素的影响。高通量16S rRNA基因测序技术被用来研究GLFL对细菌群落多样性和肠道菌群组成的影响。结果表明，GLFL显着改变了志愿者的肠道菌群的β多样性和几个门。此外，GLFL通过促进益生菌的生长，掺入乳酸杆菌（ p <0.05）和减少含有 Campylobacter 的病原体为人类提供保护。和 Aggregatibacter （ p <0.05）;但是，GLFL还具有有害作用，因为它增加了 Firmicutes / Bacteroidetes 和机会病原体（包括不动杆菌属，假单胞菌属）的数量。 em>，沙雷氏菌，链球菌，肽球菌和 S24-7 （ p < 0.05）并降低了益生菌 Lactococcus 的益生菌含量。最后，我们发现GLFL可降低志愿者的血浆低密度脂蛋白胆固醇（LDL-c）。这有助于进一步了解灵芝或其相关产品对人体的影响。

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