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首页> 外文期刊>RSC Advances >Evaluation of the efficacy and safety of Ganoderma lucidum mycelium-fermented liquid on gut microbiota and its impact on cardiovascular risk factors in human
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Evaluation of the efficacy and safety of Ganoderma lucidum mycelium-fermented liquid on gut microbiota and its impact on cardiovascular risk factors in human

机译：对肠杆菌菌丝菌丝菌丝菌丝菌丝菌丝菌丝菌丝菌丝菌丝菌丝菌液体的疗效和安全性评价及其对人体心血管危险因素的影响

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摘要

Ganoderma lucidum is a Chinese traditional medicine with various bioactivities. However, the impacts of a Ganoderma lucidum mycelium-fermented liquid (GLFL), as a promising alternative product, on the gut microbes and cardiovascular risk factors have not been explored in humans to date. In this study, the composition of polysaccharides in GLFL was analyzed, and eight volunteers were fed with GLFL to investigate its influence on gut microbes and cardiovascular risk factors. High-throughput 16S rRNA gene sequencing technique was utilized to investigate the effects of GLFL on the diversity of the bacterial communities and the composition of gut microbiota. The results demonstrated that GLFL significantly altered beta diversity and several phyla of gut microbiota in volunteers. Moreover, GLFL provided protection to humans by promoting the growth of probiotics, incorporating genus Lactobacillus (p < 0.05), and reducing pathogens containing genus Campylobacter and Aggregatibacter (p < 0.05); however, GLFL also had detrimental effects as it increased the population of Firmicutes/Bacteroidetes and opportunistic pathogens including genus Acinetobacter, Pseudomonas, Serratia, Stenotrophomonas, Peptococcus and S24-7 (p < 0.05) and reduced that of probiotics genus Lactococcus. Finally, we found that GLFL reduced plasma low-density lipoprotein cholesterol (LDL-c) in volunteers. This is helpful for further understanding the effect of Ganoderma lucidum or its related products on human body.
机译：灵芝是中国的传统中药配合各种生理活性。然而，灵芝菌丝体发酵液的影响（GLFL），作为一个有前途的替代产品，对肠道微生物与心血管危险因素尚未探索在人类迄今。在这项研究中，多糖在GLFL成分进行了分析，8名志愿者与GLFL喂食探讨其对肠道微生物与心血管危险因素的影响。高通量16S rRNA基因测序技术被用来调查GLFL对细菌群落的多样性和肠道菌群的组成影响。结果表明，GLFL显著改变的β多样性和志愿者肠道菌群的几个门类。此外，GLFL通过促进益生菌生长，掺入乳杆菌属（P <0.05），并降低包含属和弯曲杆菌Aggregatibacter（P <0.05）的病原体提供保护人类;然而，GLFL也有不利的影响，因为它增加了厚壁菌门/拟杆菌和机会致病菌包括不动杆菌属，假单胞菌属，沙雷氏菌属，寡养单胞，消化球菌和S24-7（P <0.05）的人口和降低的益生菌乳球菌属的。最后，我们发现，GLFL减少在志愿者血浆低密度脂蛋白胆固醇（LDL-C）。这对于进一步了解灵芝或对人体及其相关产品的影响很有帮助。

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  • 来源
    《RSC Advances》 |2017年第71期|共8页
  • 作者

    Wu Qizheng; Zhang Houcheng; Wang Peng Gorge; Chen Min;

  • 作者单位

    Shandong Univ Sch Life Sci Natl Glycoengn Res Ctr State Key Lab Microbial Technol Jinan 250100 Shandong Peoples R China;

    Shandong Univ Sch Life Sci Natl Glycoengn Res Ctr State Key Lab Microbial Technol Jinan 250100 Shandong Peoples R China;

    Shandong Univ Sch Life Sci Natl Glycoengn Res Ctr State Key Lab Microbial Technol Jinan 250100 Shandong Peoples R China;

    Shandong Univ Sch Life Sci Natl Glycoengn Res Ctr State Key Lab Microbial Technol Jinan 250100 Shandong Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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