38–42) derived '/> Aβ<sub>1–42</sub> C-terminus fragment derived peptides prevent the self-assembly of the parent peptide
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Aβ1–42 C-terminus fragment derived peptides prevent the self-assembly of the parent peptide

机译：Aβ 1-42 C端片段衍生肽阻止亲本肽的自组装

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摘要

In an attempt to design Aβ aggregation inhibitors to combat Alzheimer's disease, herein we report a full peptide scan performed on a pentapeptide fragment (Aβ38–42) derived from the C-terminus of Aβ1–42 peptide. More than thirty new peptides were synthesized and tested for their inhibition activity towards Aβ self-assembly. In the cell viability assay, when co-incubated with Aβ, three peptides were found to completely prevent the toxicity induced by Aβ aggregation. Most active pentapeptides were also studied by ThT fluorescence assay and the results were well correlated to the MTT study. The inhibition potential of a pentapeptide (15) was further confirmed by CD spectroscopy and transmission electron microscopy.
机译：为了设计对抗Azheimer病的Aβ聚集抑制剂，我们在此报告了对源自C-的五肽片段（Aβ 38-42 ）进行的全肽扫描Aβ 1-42 肽的末端。合成了三十多种新肽，并测试了它们对Aβ自组装的抑制活性。在细胞活力测定中，当与Aβ共同孵育时，发现三种肽可以完全防止Aβ聚集诱导的毒性。还通过ThT荧光测定法研究了大多数活性五肽，结果与MTT研究具有很好的相关性。五肽（15​​）的抑制潜力通过CD光谱法和透射电子显微镜进一步证实。

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