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首页> 外文期刊>RSC Advances >Simultaneous optimization of ultrasonic-assisted extraction of antioxidant and anticoagulation activities of compounds from Leonurus japonicus Houtt. by response surface methodology
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Simultaneous optimization of ultrasonic-assisted extraction of antioxidant and anticoagulation activities of compounds from Leonurus japonicus Houtt. by response surface methodology

机译：同时优化超声波辅助提取益母草中化合物的抗氧化剂和抗凝活性。通过响应面法

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Leonurus japonicus Houtt. is a herbaceous annual of the Lamiaceae family with pantropical distribution; it is called motherwort in China. It plays important roles in anticoagulation and antioxidation. This study aimed to explore the optimization of ultrasound-assisted extraction of multiple compounds from motherwort as well as their antioxidant and anticoagulation activities using response surface methodology. Box–Behnken design was employed to optimize three significant influences, namely extraction time, extraction temperature and ethanol concentration. The optimum extraction parameters acquired based on a combination of the yield of the target compounds and their antioxidant and anticoagulation activities were an extraction time of 38.2 min, an extraction temperature of 30.0 °C, an ethanol concentration of 48.9% (v/v), a solid–liquid ratio of 30.0 mL g ~(?1) and an ultrasonic power of 500.0 W. Under the optimal conditions, the maximal yield of the anticoagulation and antioxidant compounds of motherwort was 0.994%; the thrombin time was 19.872 s; prothrombin time was 8.270 s; the activated partial thromboplastin time was 15.535 s; the fibrinogen was 1.420 g L ~(?1) ; and the 1,1-diphenyl-2-picrylhydrazyl free radical scavenging activity was 1.503 mg mL ~(?1) . The optimized conditions model showed a good correlation between the predicted and experimental values. According to the results of our study, the optimization extraction significantly enabled study of the anticoagulation and antioxidant activities of compounds in motherwort; this may contribute to future research on the pharmacological activities of motherwort.
机译：益母草。是唇形科的草本一年生植物，具有泛热带分布;在中国被称为益母草。它在抗凝和抗氧化中起重要作用。这项研究的目的是探索使用响应表面方法从超声中益母草中多种化合物的超声辅助提取及其抗氧化和抗凝活性的优化。采用Box–Behnken设计来优化三个重要影响，即提取时间，提取温度和乙醇浓度。根据目标化合物的收率及其抗氧化剂和抗凝活性的组合获得的最佳提取参数为：提取时间为38.2分钟，提取温度为30.0°C，乙醇浓度为48.9％（v / v），固液比为30.0 mL g〜（？1），超声功率为500.0W。在最佳条件下，益母草的抗凝和抗氧化剂化合物的最大收率为0.994％。凝血酶时间为19.872 s;凝血酶原时间为8.270 s;活化的部分凝血活酶时间为15.535 s;纤维蛋白原为1.420 g L〜（？1）; 1，1-二苯基-2-吡啶并肼基清除自由基的活性为1.503mgmL〜（？1）。优化的条件模型显示了预测值和实验值之间的良好相关性。根据我们的研究结果，优化提取显着有助于研究益母草中化合物的抗凝和抗氧化活性。这可能有助于对益母草药理活性的进一步研究。

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