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Extracellular probiotic lipase capped silver nanoparticles as highly efficient broad spectrum antimicrobial agents

机译：细胞外益生菌脂肪酶封端的银纳米颗粒作为高效的广谱抗菌剂

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The microbial resistance to different drugs due to excessive usage of antibiotics in various domains has become a serious environmental threat in recent years. This gave the impetus to researchers to find alternatives that do not lead to multi-drug resistant microbes. In this backdrop, silver nanoparticles (Ag NPs) have become a popular choice due to their potential broad spectrum of antimicrobial attributes. Recent literature caution that about 400 metric tons of Ag NPs are synthesized annually all over the world that could cause environmental hazards when used at higher concentrations than the toxicity limit. However, most of the literature reports use higher concentrations of Ag NPs and exposure to such concentrations may lead to environmental and health hazards. In this study, a series of Ag NPs have been synthesized using a lipase derived from a probiotic source Lactobacillus plantarum as the stabilizing agent. The Ag NPs synthesized through different combinations of lipase and AgNO _(3) are characterized using various techniques such as UV-visible spectroscopy, FT-IR, ED-XRF, DLS and HR-TEM. The lipase capped Ag NPs have been studied for their antimicrobial activity against representative microbes such as Pseudomonas putida , Staphylococcus aureus and Aspergillus niger . Our initial results reveal that the lipase capped Ag NPs possess high potential towards broad spectrum antimicrobial applications at concentrations much lower than the toxicity limit of the standard model, zebra fish.
机译：近年来，由于在各个领域过量使用抗生素而导致的对不同药物的微生物耐药性已成为严重的环境威胁。这推动了研究人员寻找不会导致多重耐药微生物的替代品。在这种背景下，银纳米颗粒（Ag NPs）由于其潜在的广谱抗菌特性而成为一种流行的选择。最近的文献警告说，全世界每年合成约400公吨的Ag NP，如果以高于毒性极限的浓度使用，可能会造成环境危害。然而，大多数文献报道使用较高浓度的银纳米颗粒，暴露于这种浓度可能会导致环境和健康危害。在这项研究中，使用源自益生菌来源的植物乳杆菌的脂肪酶作为稳定剂合成了一系列Ag NP。通过脂肪酶和AgNO_（3）的不同组合合成的Ag NPs使用多种技术进行表征，例如紫外可见光谱，FT-IR，ED-XRF，DLS和HR-TEM。研究了脂肪酶封端的Ag NPs对代表性微生物如恶臭假单胞菌，金黄色葡萄球菌和黑曲霉的抗菌活性。我们的初步结果表明，以脂酶封端的Ag NP具有很高的潜力，其浓度远低于标准模型斑马鱼的毒性极限，可用于广谱抗菌。

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