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Extracellular probiotic lipase capped silver nanoparticles as highly efficient broad spectrum antimicrobial agents

机译：细胞外益生菌粘贴银纳米颗粒作为高效广谱抗微生物剂

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摘要

The microbial resistance to different drugs due to excessive usage of antibiotics in various domains has become a serious environmental threat in recent years. This gave the impetus to researchers to find alternatives that do not lead to multi-drug resistant microbes. In this backdrop, silver nanoparticles (Ag NPs) have become a popular choice due to their potential broad spectrum of antimicrobial attributes. Recent literature caution that about 400 metric tons of Ag NPs are synthesized annually all over the world that could cause environmental hazards when used at higher concentrations than the toxicity limit. However, most of the literature reports use higher concentrations of Ag NPs and exposure to such concentrations may lead to environmental and health hazards. In this study, a series of Ag NPs have been synthesized using a lipase derived from a probiotic source Lactobacillus plantarum as the stabilizing agent. The Ag NPs synthesized through different combinations of lipase and AgNO3 are characterized using various techniques such as UV-visible spectroscopy, FT-IR, ED-XRF, DLS and HR-TEM. The lipase capped Ag NPs have been studied for their antimicrobial activity against representative microbes such as Pseudomonas putida, Staphylococcus aureus and Aspergillus niger. Our initial results reveal that the lipase capped Ag NPs possess high potential towards broad spectrum antimicrobial applications at concentrations much lower than the toxicity limit of the standard model, zebra fish.
机译：由于近年来，由于各个域中的抗生素过度使用的过度使用而导致的不同药物的微生物耐药成为严重的环境威胁。这给研究人员提供了动力，找到了不会导致多毒性微生物的替代品。在该背景中，由于其潜在的广谱抗微生物属性，银纳米颗粒（Ag NPS）已成为一种流行的选择。最近的文献注意，大约400公吨的AG NPS每年都在全球中合成，可能在比毒性极限更高的浓度时造成环境危害。然而，大多数文献报告使用较高浓度的AG NPS，并且暴露于这种浓度可能导致环境和健康危害。在该研究中，已经使用衍生自益生菌来源乳杆菌作为稳定剂的脂肪酶合成了一系列Ag NPS。银纳米颗粒通过脂肪酶的不同组合的合成和AgNO3使用各种技术，例如紫外 - 可见光谱，FT-IR，ED-XRF，DLS和HR-TEM表征。已经研究了脂肪酶封端的AG NPS针对代表性微生物的抗微生物活性研究，例如假单胞菌玻璃葡萄球菌，金黄色葡萄球菌和曲霉尼日尔。我们的初步结果表明，脂肪酶封装AG NPS在远低于标准模型的毒性极限的浓度下具有高频谱抗微生物应用的高潜力。

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  • 来源
    《RSC Advances》 |2018年第55期|共8页
  • 作者

    Khan Imran; Sivasankaran Nivetha; Nagarjuna Ravikiran; Ganesan Ramakrishnan; Dutta Jayati Ray;

  • 作者单位

    BITS Pilani Dept Biol Sci Hyderabad Campus Hyderabad 500078 Telangana India;

    BITS Pilani Dept Biol Sci Hyderabad Campus Hyderabad 500078 Telangana India;

    BITS Pilani Dept Chem Hyderabad Campus Hyderabad 500078 Telangana India;

    BITS Pilani Dept Chem Hyderabad Campus Hyderabad 500078 Telangana India;

    BITS Pilani Dept Biol Sci Hyderabad Campus Hyderabad 500078 Telangana India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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