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首页> 外文期刊>RSC Advances >Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair
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Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

机译：羟基磷灰石纳米线/胶原弹性多孔纳米复合材料及其在骨缺损修复中的增强性能

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The synthetic bone grafts that mimic the composition and structure of human natural bone exhibit great potential for application in bone defect repair. In this study, a biomimetic porous nanocomposite consisting of ultralong hydroxyapatite nanowires (UHANWs) and collagen (Col) with 66.7 wt% UHANWs has been prepared by the freeze drying process and subsequent chemical crosslinking. Compared with the pure collagen as a control sample, the biomimetic UHANWs/Col porous nanocomposite exhibits significantly improved mechanical properties. More significantly, the rehydrated UHANWs/Col nanocomposite exhibits an excellent elastic behavior. Moreover, the biomimetic UHANWs/Col porous nanocomposite has a good degradable performance with a sustained release of Ca and P elements, and can promote the adhesion and spreading of mesenchymal stem cells. The in vivo evaluation reveals that the biomimetic UHANWs/Col porous nanocomposite can significantly enhance bone regeneration compared with the pure collagen sample. After 12 weeks implantation, the woven bone and lamellar bone are formed throughout the entire UHANWs/Col porous nanocomposite, and connect directly with the host bone to construct a relatively normal bone marrow cavity, leading to successful osteointegration and bone reconstruction. The as-prepared biomimetic UHANWs/Col porous nanocomposite is promising for applications in various fields such as bone defect repair.
机译：模仿人类天然骨的组成和结构的合成骨移植物在骨缺损修复中具有巨大的应用潜力。在这项研究中，通过冷冻干燥过程和随后的化学交联，制备了由超长羟基磷灰石纳米线（UHANWs）和具有66.7 wt％UHANWs的胶原蛋白（Col）组成的仿生多孔纳米复合材料。与纯胶原蛋白作为对照样品相比，仿生UHANWs / Col多孔纳米复合材料的机械性能显着提高。更重要的是，再水合的UHANWs / Col纳米复合材料表现出出色的弹性性能。此外，仿生UHANWs / Col多孔纳米复合材料具有良好的可降解性能，并持续释放Ca和P元素，并且可以促进间充质干细胞的粘附和扩散。体内评估显示，与纯胶原蛋白样品相比，仿生UHANWs / Col多孔纳米复合材料可显着增强骨骼再生。植入12周后，在整个UHANWs / Col多孔纳米复合材料中形成了编织骨和层状骨，并直接与宿主骨连接以构建相对正常的骨髓腔，从而成功实现了骨整合和骨重建。制备的仿生UHANWs / Col多孔纳米复合材料有望在各种领域（如骨缺损修复）中应用。

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