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PDMS-based microfluidic devices using commoditized PCBs as masters with no specialized equipment required

机译：基于PDMS的微流控设备，使用商品化的PCB作为主设备，无需专用设备

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Designed printed circuit boards (PCBs) are alternative substrates for master mold construction of microfluidic devices. However, the rough supportive material molds rough replicas and causes difficulty in device sealing. To overcome this difficulty, a copper layer is used to generate a smooth surface. Some other researchers have used thermoplastic elastomers, which are typically much easier to bond, instead of the general polymer polydimethysiloxane (PDMS). This study presents an extremely simple approach for fabricating PDMS-based microfluidic devices using PCBs as masters. Unlike those reported in the previous studies, commoditized PCBs fabricated at a common PCB manufactory were directly used as the master molds. Two layers of semi-cured silicone of a distinct base to curing agent ratios were bonded together by additional curing. Efficient bonding was accomplished and avoided insufficient adhesion due to the rough surfaces of the PDMS replicas. Highly monodisperse droplets with polydispersity values smaller than 1% were stably formed using the easy fabricated devices. Essential operations in droplet microfluidics were reliably conducted in the PDMS-based devices. Moreover, the droplets were orderly sorted by the microstructures in the fabricated multi-height devices. The fabrication process provided a simple, convenient and reliable approach to prepare the general polymer PDMS-based microfluidic devices with a minimal requirement for equipment.
机译：设计的印刷电路板（PCB）是微流控设备主模具构造的替代基板。但是，粗糙的支撑材料会模制粗糙的复制品，并导致装置密封困难。为了克服这个困难，铜层用于产生光滑的表面。其他一些研究人员使用的是热塑性弹性体，通常比通常的聚合物聚二甲基硅氧烷（PDMS）更容易粘合。这项研究提出了一种非常简单的方法，以PCB为主体来制造基于PDMS的微流体设备。与之前的研究不同，在普通PCB制造厂制造的商品化PCB被直接用作母模。通过另外的固化将具有不同的基础剂与固化剂比率的两层半固化的硅氧烷粘合在一起。实现了有效的粘合，避免了由于PDMS复制品的粗糙表面而导致的粘合不足。使用容易制造的装置稳定地形成多分散度值小于1％的高度单分散的液滴。在基于PDMS的设备中可靠地进行了微滴微滴中的基本操作。而且，在制造的多高度装置中，液滴通过微结构被有序地分类。该制造过程提供了一种简单，方便和可靠的方法来制备通用的基于PDMS的微流控设备，而对设备的要求却最低。

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