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PDMS-based microfluidic devices using commoditized PCBs as masters with no specialized equipment required

机译：基于PDMS的微流体装置，使用商品化PCB作为大师，无需专门设备

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摘要

Designed printed circuit boards (PCBs) are alternative substrates for master mold construction of microfluidic devices. However, the rough supportive material molds rough replicas and causes difficulty in device sealing. To overcome this difficulty, a copper layer is used to generate a smooth surface. Some other researchers have used thermoplastic elastomers, which are typically much easier to bond, instead of the general polymer polydimethysiloxane (PDMS). This study presents an extremely simple approach for fabricating PDMS-based microfluidic devices using PCBs as masters. Unlike those reported in the previous studies, commoditized PCBs fabricated at a common PCB manufactory were directly used as the master molds. Two layers of semicured silicone of a distinct base to curing agent ratios were bonded together by additional curing. Efficient bonding was accomplished and avoided insufficient adhesion due to the rough surfaces of the PDMS replicas. Highly monodisperse droplets with polydispersity values smaller than 1% were stably formed using the easy fabricated devices. Essential operations in droplet microfluidics were reliably conducted in the PDMS-based devices. Moreover, the droplets were orderly sorted by the microstructures in the fabricated multi-height devices. The fabrication process provided a simple, convenient and reliable approach to prepare the general polymer PDMS-based microfluidic devices with a minimal requirement for equipment.
机译：设计的印刷电路板（PCB）是用于微流体装置的母模结构的替代基板。然而，粗糙的支撑材料模具粗糙的复制品并导致装置密封难以。为了克服这种困难，铜层用于产生光滑的表面。一些其他研究人员使用了热塑性弹性体，其通常更容易粘合，而不是一般聚合物聚二甲基硅氧烷（PDMS）。本研究提出了一种非常简单的方法，用于使用PCB作为主体制造基于PDMS的微流体装置。与先前研究中报道的那些不同，在普通PCB制造厂制造的商品化PCB直接用作母模。通过额外的固化将两层不同碱的固化剂碱的半层结合在一起。完成了高效键合，并避免由于PDMS复制品的粗糙表面引起的粘附不足。使用易于制造的装置稳定地形成具有小于1％的多分散值的高度单分散液滴。在基于PDMS的器件中可靠地进行液滴微流体的基本操作。此外，通过制造的多高度器件中的微结构有序地排序液滴。制造方法提供了一种简单，方便且可靠的方法来制备具有最小化设备的基于聚合物PDMS的微流体装置。

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  • 来源
    《RSC Advances》 |2017年第50期|共7页
  • 作者

    Tu Jing; Qiao Yi; Feng Haiqing; Li Junji; Fu Jiye; Liang Fupeng; Lu Zuhong;

  • 作者单位

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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