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Hierarchical macroporeano surface regulates stem cell fate through a ROCK-related signaling pathway

机译：分级大孔/纳米表面通过ROCK相关信号通路调节干细胞命运

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A hierarchical macroporeano implant surface has been considered as an effective approach to endow biomaterials with better osteogenic performance and long-term stability. The involvement of rho-associated kinase (ROCK) in hierarchical surface-induced osteogenesis, which might originate from the synergistic effect of macropores and nanostructures on cytoskeleton distribution, has previously been demonstrated. However, the underlying intracellular mechanisms are still largely unknown, and thus, this precludes the precise understanding of its cell surface interaction. In this study, it has been further proved that a ROCK-related signaling pathway might be important in translating the surface cues into BMSC fate. Results showed that different bone marrow stromal cell (BMSC) cytoskeleton distributions and corresponding ROCK activity, consequently exerted distinct effects on the FAK-ERK1/2 signaling pathway, which was finally responsible for the BMSC osteogenic differentiation performance. This study has indicated the probable role of ROCK-regulated cytoskeleton tension and its downstream signaling pathway in mediating the signals from topography cues for desirable osteogenic differentiation and furthermore, a probably distinct mechanotransduction process concerning different scales of topographies has been proposed, which might provide insights for use in advanced biomaterial surface design to attain better osteogenesis.
机译：分级的大孔/纳米植入物表面已被认为是赋予生物材料更好的成骨性能和长期稳定性的有效方法。先前已证明，rho相关激酶（ROCK）参与分层表面诱导的成骨作用，这可能源于大孔和纳米结构对细胞骨架分布的协同作用。然而，基本的细胞内机制仍然是很大程度上未知的，因此，这排除了对其细胞表面相互作用的精确理解。在这项研究中，进一步证明了与ROCK有关的信号通路可能在将表面线索转化为BMSC命运方面很重要。结果表明，不同的骨髓基质细胞（BMSC）细胞骨架分布和相应的ROCK活性，从而对FAK-ERK1 / 2信号通路产生不同的影响，最终导致BMSC成骨分化性能。这项研究表明，ROCK调节的细胞骨架张力及其下游信号传导途径可能在介导地形线索提示的成骨分化信号中起着重要作用，此外，有人提出了关于不同规模地形的可能不同的机械转导过程，这可能会提供一些见解。用于先进的生物材料表面设计以获得更好的成骨作用。

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