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Differentiation induction and maturation from pluripotent cells to hepatocyte-like cells by regulating Wnt signaling pathway
Differentiation induction and maturation from pluripotent cells to hepatocyte-like cells by regulating Wnt signaling pathway
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机译:通过调节Wnt信号通路从多能细胞向肝样细胞的分化诱导和成熟
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摘要
Provided are improved methods using Glycogen synthase kinase 3 (GSK3) inhibitors by which endodermal cells, notably endodermal cells derived from human pluripotent stem cells (hPS), such as but not limited to hiPS-cells and hES-cells may be differentiated into hepatocyte like cells. The specific modulation of wingless integration gene (WNT)-signalling pathway and use of GSK3 inhibitors achieve direct differentiation and maturation of hepatocytes derived from human pluripotent stem (hPS) cells. GSK-3 inhibitors, when added to the growth medium at certain developmental stages, leads to more mature and functional features for the hepatocyte like cells as well as more pure and homogenous populations of hepatocyte like cells. Provided are also hepatocyte like cells obtained by these methods as well as compositions comprising them.
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