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首页> 外文期刊>RSC Advances >Comparison between mandibular and femur derived bone marrow stromal cells: osteogenic and angiogenic potentials in vitro and bone repairing ability in vivo
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Comparison between mandibular and femur derived bone marrow stromal cells: osteogenic and angiogenic potentials in vitro and bone repairing ability in vivo

机译：下颌骨和股骨来源的骨髓基质细胞的比较：体外成骨和血管生成潜力以及体内骨修复能力

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As seed cells for bone tissue engineering, bone marrow stromal cells (BMSCs) have multiple differentiation potential. Prior studies have demonstrated that jaw bone has distinct osteogenic characteristics and different bone repairing capability from limb bone. In order to compare the promotion of bone regeneration as seed cells between maxillofacial derived BMSCs (M-BMSCs) and femur derived BMSCs (F-BMSCs) of SD rats, their proliferation and potential multipotent differentiation abilities, osteogenic differentiation and angiogenic factor secretion were investigated and compared. Moreover, the M-BMSCs and F-BMSCs were seeded on β-tricalcium phosphate bioceramic microspheres, and implanted into alveolar bone crest. The bone regeneration ability induced by the M-BMSCs and F-BMSCs was examined. The results showed that M-BMSCs had better osteogenic capability and angiogenic tendency than those of F-BMSCs both in vitro and in vivo. M-BMSCs might be the ideal stem seed cell sources for bone regeneration and bone tissue engineering applications.
机译：作为用于骨组织工程的种子细胞，骨髓基质细胞（BMSC）具有多种分化潜能。先前的研究表明，颌骨与肢体骨具有不同的成骨特性和不同的骨修复能力。为了比较SD大鼠上颌面来源的BMSCs（M-BMSCs）和股骨来源的BMSCs（F-BMSCs）之间作为种子细胞的骨再生促进作用，研究了它们的增殖和潜在的多能分化能力，成骨分化和血管生成因子分泌。并进行比较。此外，将M-BMSC和F-BMSC接种在β-磷酸三钙生物陶瓷微球上，并植入牙槽骨al中。检查了由M-BMSC和F-BMSC诱导的骨再生能力。结果表明，无论是在体外还是在体内，M-BMSCs均具有比F-BMSCs更好的成骨能力和血管生成趋势。 M-BMSC可能是用于骨再生和骨组织工程应用的理想干种子细胞来源。

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