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首页> 外文期刊>RSC Advances >Study on the formation and properties of red blood cell-like Fe3O4/TbLa3(Bim)12/PLGA composite particles
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Study on the formation and properties of red blood cell-like Fe3O4/TbLa3(Bim)12/PLGA composite particles

机译：红细胞样Fe3O4 / TbLa3（Bim）12 / PLGA复合颗粒的形成与性能研究

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Besides the particle size and surface performance, the shape also plays a key role in drug delivery systems. Red blood cells are the most abundant blood cells in the human body, and are excellent oxygen carriers, due to their unique biconcave discoid shape. In this study, red blood cell (RBC)-like Fe _(3) O _(4) /TbLa _(3) (Bim) _(12) /poly(lactic- co -glycolic acid) (PLGA) composite particles, with magnetic response and bioimaging functions, were prepared by electrospraying. Various electrospraying parameters, such as solvent, PLGA concentration, collecting distance and solution flow rate were investigated in detail to attempt to obtain RBC-like composite particles. The size distribution, morphology, structure, and hydrophobicity–hydrophilicity of particles were characterized. The results revealed the RBC-like Fe _(3) O _(4) /TbLa _(3) (Bim) _(12) /PLGA composite particles exhibited a strong green fluorescence and good magnetic behavior even when incubated with cells. Furthermore, the intensity of the magnetization and fluorescence can be adjusted by changing the contents of Fe _(3) O _(4) and TbLa _(3) (Bim) _(12) . The effect on cell viability of the RBC-like Fe _(3) O _(4) /TbLa _(3) (Bim) _(12) /PLGA composite particles was evaluated in A549 cells and RBCs, and it was determined to have low cytotoxicity and excellent blood biocompatibility, suggesting that it is a promising candidate for application in drug delivery, targeting and tracking.
机译：除了粒径和表面性能外，形状在药物输送系统中也起着关键作用。红细胞由于其独特的双凹盘状形状，是人体中最丰富的血细胞，并且是极好的氧气载体。在这项研究中，类红细胞（RBC）的Fe _（3）O _（4）/ TbLa _（3）（Bim）_（12）/聚（乳酸-乙醇酸）（PLGA）复合颗粒通过电喷雾制备了具有磁响应和生物成像功能的。详细研究了各种电喷雾参数，例如溶剂，PLGA浓度，收集距离和溶液流速，以尝试获得类似RBC的复合颗粒。表征了颗粒的尺寸分布，形态，结构和疏水性-亲水性。结果表明，即使与细胞一起温育，类似RBC的Fe _（3）O _（4）/ TbLa _（3）（Bim）_（12）/ PLGA复合颗粒也显示出强绿色荧光和良好的磁性。此外，可以通过改变Fe _（3）O _（4）和TbLa _（3）（Bim）_（12）的含量来调节磁化强度和荧光强度。在A549细胞和RBC中评估了RBC样Fe _（3）O _（4）/ TbLa _（3）（Bim）_（12）/ PLGA复合颗粒对细胞活力的影响，并确定具有低细胞毒性和优异的血液生物相容性，表明它是在药物递送，靶向和追踪中应用的有希望的候选者。

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