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首页> 外文期刊>RSC Advances >Study on the formation and properties of red blood cell-like Fe3O4/TbLa3(Bim)(12)/PLGA composite particles
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Study on the formation and properties of red blood cell-like Fe3O4/TbLa3(Bim)(12)/PLGA composite particles

机译：红细胞样Fe3O4 / TBLA3（BIM）（12）/ PLGA复合颗粒的形成与性能研究

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摘要

Besides the particle size and surface performance, the shape also plays a key role in drug delivery systems. Red blood cells are the most abundant blood cells in the human body, and are excellent oxygen carriers, due to their unique biconcave discoid shape. In this study, red blood cell (RBC)-like Fe3O4/TbLa3(Bim)(12)/poly(lactic-co-glycolic acid) (PLGA) composite particles, with magnetic response and bioimaging functions, were prepared by electrospraying. Various electrospraying parameters, such as solvent, PLGA concentration, collecting distance and solution flow rate were investigated in detail to attempt to obtain RBC-like composite particles. The size distribution, morphology, structure, and hydrophobicity-hydrophilicity of particles were characterized. The results revealed the RBC-like Fe3O4/TbLa3(Bim)(12)/PLGA composite particles exhibited a strong green fluorescence and good magnetic behavior even when incubated with cells. Furthermore, the intensity of the magnetization and fluorescence can be adjusted by changing the contents of Fe3O4 and TbLa3(Bim)(12). The effect on cell viability of the RBC-like Fe3O4/TbLa3(Bim)(12)/PLGA composite particles was evaluated in A549 cells and RBCs, and it was determined to have low cytotoxicity and excellent blood biocompatibility, suggesting that it is a promising candidate for application in drug delivery, targeting and tracking.
机译：除了粒度和表面性能外，形状也在药物递送系统中起着关键作用。红细胞是人体中最丰富的血细胞，并且是优异的氧载体，因为它们独特的双亮度圆润形状。在该研究中，通过电喷雾制备红细胞（RBC） - 麦克妥FE3O4 / TBLA3（BIM）（12）/聚（乳酸二乙醇酸）（PLGA）复合颗粒，具有磁响应和生物分析功能。详细研究了各种电喷雾参数，例如溶剂，PLGA浓度，收集距离和溶液流速，以试图获得类似RBC样复合颗粒。表征粒子的尺寸分布，形态，结构和疏水性 - 亲水性。结果显示出RBC样Fe3O4 / TBLA3（BIM）（12）/ PLGA复合颗粒即使与细胞孵育时也表现出强大的绿色荧光和良好的磁性行为。此外，可以通过改变Fe3O4和TBLA3（BIM）（12）的含量来调节磁化和荧光的强度。在A549细胞和RBC中评估了对RBC样Fe3O4 / TBLA3（BIM）（12）/ PLGA复合颗粒的细胞活力的影响，并确定具有低细胞毒性和优异的血液生物相容性，这表明它是一个有前途的候选药物递送，瞄准和跟踪应用。

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  • 来源
    《RSC Advances》 |2018年第23期|共14页
  • 作者

    Li Ping; Qi Bing; Li Kun; Xu Junwei; Liu Meili; Gu Xuenan; Niu Xufeng; Fan Yubo;

  • 作者单位

    Beihang Univ Minist Educ Key Lab Biomech &

    Mechanobiol Sch Biol Sci &

    Med Engn Beijing 100083 Peoples R China;

    Beihang Univ Minist Educ Key Lab Biomech &

    Mechanobiol Sch Biol Sci &

    Med Engn Beijing 100083 Peoples R China;

    Beihang Univ Minist Educ Key Lab Biomech &

    Mechanobiol Sch Biol Sci &

    Med Engn Beijing 100083 Peoples R China;

    Beihang Univ Minist Educ Key Lab Biomech &

    Mechanobiol Sch Biol Sci &

    Med Engn Beijing 100083 Peoples R China;

    Beihang Univ Minist Educ Key Lab Biomech &

    Mechanobiol Sch Biol Sci &

    Med Engn Beijing 100083 Peoples R China;

    Beihang Univ Minist Educ Key Lab Biomech &

    Mechanobiol Sch Biol Sci &

    Med Engn Beijing 100083 Peoples R China;

    Beihang Univ Minist Educ Key Lab Biomech &

    Mechanobiol Sch Biol Sci &

    Med Engn Beijing 100083 Peoples R China;

    Beihang Univ Minist Educ Key Lab Biomech &

    Mechanobiol Sch Biol Sci &

    Med Engn Beijing 100083 Peoples R China;

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