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首页> 外文期刊>RSC Advances >Controlled chemical synthesis of CaO2 particles coated with polyethylene glycol: characterization of crystallite size and oxygen release kinetics
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Controlled chemical synthesis of CaO2 particles coated with polyethylene glycol: characterization of crystallite size and oxygen release kinetics

机译：聚乙二醇包覆的CaO 2 颗粒的受控化学合成：微晶尺寸和氧气释放动力学的表征

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Incorporating oxygen generating substances into tissue constructs is one of the methods for increasing cell survival under hypoxic condition. Calcium peroxide from alkaline earth metal peroxide groups has been proposed as an appropriate compound for supplying sufficient oxygen to cells within the scaffolds. The high surface-to-volume ratio of CaO2 particles can lead to an increase in oxygen generation ability over a particular time interval. One objective of this study was to decrease calcium peroxide crystallite size via changing the local supersaturation level by controlling the reactant addition rate during coprecipitation synthesis. Therefore, the effect of hydrogen peroxide addition rate on the crystallite size, particle size distribution, and CaO2 purity, which have not been studied before, were discussed. It was found that the crystallite size of CaO2 depends upon the reactant addition rate, and the crystallite size decreased from 111 to 37?nm when the addition rate increased from 0.29 to 0.88 ml min?1. Furthermore, after determining the hydrogen peroxide addition rate, a facile method was developed to prepare CaO2 particles with polyethylene glycol coating for the first time. The aim of PEG coating was to improve redispersion of the precipitated CaO2 particles. Thermogravimetric analysis was used to measure the content of adsorbed PEG on the surface of the particles. Eventually, the oxygen release profile of PEG-coated calcium peroxide particles demonstrated that the release kinetics is dependent on the pH value of the exterior medium, diffusion through the calcium carbonate product layer, and molar ratios of PEG to calcium.
机译：将产生氧的物质掺入组织构建物中是在缺氧条件下增加细胞存活率的方法之一。已经提出了来自碱土金属过氧化物基团的过氧化钙作为用于向支架内的细胞供应足够的氧的合适化合物。 CaO 2 颗粒的高体积比可导致在特定时间间隔内氧气生成能力的提高。这项研究的一个目的是通过控制共沉淀合成过程中的反应物添加速率，通过改变局部过饱和水平来降低过氧化钙微晶尺寸。因此，讨论了过氧化氢的添加速率对微晶尺寸，粒径分布和CaO 2 纯度的影响，而这是以前没有研究过的。结果发现，CaO 2 的晶粒尺寸取决于反应物的添加速率，当添加速率从0.29增加到37？nm时，晶粒尺寸从111减小到37？nm。 0.88毫升min ？1 。此外，在确定过氧化氢的添加量后，开发了一种简便的方法来首次制备带有聚乙二醇涂层的CaO 2 颗粒。 PEG包覆的目的是改善沉淀的CaO 2 颗粒的再分散。使用热重分析法来测量颗粒表面上吸附的PEG的含量。最终，涂覆有PEG的过氧化钙颗粒的氧气释放曲线表明，释放动力学取决于外部介质的pH值，通过碳酸钙产物层的扩散以及PEG与钙的摩尔比。

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