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首页> 外文期刊>RSC Advances >Controlled chemical synthesis of CaO2 particles coated with polyethylene glycol: characterization of crystallite size and oxygen release kinetics
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Controlled chemical synthesis of CaO2 particles coated with polyethylene glycol: characterization of crystallite size and oxygen release kinetics

机译：涂有聚乙二醇的CaO2颗粒的控制化学合成：结晶尺寸和氧释放动力学的表征

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Incorporating oxygen generating substances into tissue constructs is one of the methods for increasing cell survival under hypoxic condition. Calcium peroxide from alkaline earth metal peroxide groups has been proposed as an appropriate compound for supplying sufficient oxygen to cells within the scaffolds. The high surface-to-volume ratio of CaO2 particles can lead to an increase in oxygen generation ability over a particular time interval. One objective of this study was to decrease calcium peroxide crystallite size via changing the local supersaturation level by controlling the reactant addition rate during coprecipitation synthesis. Therefore, the effect of hydrogen peroxide addition rate on the crystallite size, particle size distribution, and CaO2 purity, which have not been studied before, were discussed. It was found that the crystallite size of CaO2 depends upon the reactant addition rate, and the crystallite size decreased from 111 to 37 nm when the addition rate increased from 0.29 to 0.88 ml min(-1). Furthermore, after determining the hydrogen peroxide addition rate, a facile method was developed to prepare CaO2 particles with polyethylene glycol coating for the first time. The aim of PEG coating was to improve redispersion of the precipitated CaO2 particles. Thermogravimetric analysis was used to measure the content of adsorbed PEG on the surface of the particles. Eventually, the oxygen release profile of PEGcoated calcium peroxide particles demonstrated that the release kinetics is dependent on the pH value of the exterior medium, diffusion through the calcium carbonate product layer, and molar ratios of PEG to calcium.
机译：将氧气产生物质掺入组织构建体中是在缺氧条件下增加细胞存活的方法之一。已经提出了来自碱土金属过氧化氢基团的过氧化物作为适当的化合物，用于向支架内的细胞提供足够的氧气。 CaO2颗粒的高度体积比可以导致特定时间间隔内的氧收能力的增加。本研究的一个目的是通过控制共沉淀合成期间的反应性添加速率来通过改变局部过饱和水平来降低过氧化物微晶尺寸。因此，对微晶尺寸过氧化氢添加率，粒度分布，和过氧化钙的纯度，还没有被研究过的效果，进行了讨论。结果发现，过氧化钙的微晶尺寸取决于反应物的加入速率，晶体尺寸从111％下降到37纳米时添加速率从0.29提高至0.88毫升分钟（-1）。此外，在确定的过氧化氢添加率之后，一个浅显的方法被开发用于与聚乙二醇涂层首次制备过氧化钙颗粒。 PEG涂层的目的是改善沉淀的CaO2颗粒的重新分散。热重分析用于测量吸附栓的吸附栓的含量。最终，PEGcoated过氧化钙粒子的氧的释放曲线表明，释放动力学依赖于外部介质的pH值，通过碳酸钙产物层的扩散，和PEG与钙摩尔比。

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