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首页> 外文期刊>RSC Advances >Self-assembled nanoparticles based on a carboxymethylcellulose–ursolic acid conjugate for anticancer combination therapy
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Self-assembled nanoparticles based on a carboxymethylcellulose–ursolic acid conjugate for anticancer combination therapy

机译：基于羧甲基纤维素-熊果酸缀合物的自组装纳米颗粒用于抗癌联合治疗

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摘要

A new self-assembled nanoparticle platform based on a carboxymethylcellulose (CMC)–ursolic acid (UA) conjugate is presented for the first time. The CMC–UA conjugate was synthesized by introducing the hydrophobic drug UA into the hydrophilic polymer molecule CMC, and then another anticancer drug, hydroxycamptothecin (HCPT), was encapsulated into the self-assembled nanoparticles (CMC–UA/HCPT NPs) of the conjugate formed by the nanoprecipitation method. The obtained nanoparticles possessed appropriate size (～40 nm), high encapsulation efficiency (～17.53 wt% HCPT) and drug-loading efficiency (～29.62 wt% UA). Cell experiments indicated that CMC–UA/HCPT NPs exhibited higher cytotoxicity than free UA and free HCPT, owing to the longer blood retention time than free drug (7.3-fold UA, 2.5-fold HCPT) and effective cellular uptake. Anti-tumor capacity, mice survival rate and tumor growth inhibition of UA and HCPT were also significant. Moreover, the evaluation of the side effects clearly and elaborately certified that NPs could reduce the risk of hypersensitivity reactions substantially. Therefore, CMC–UA/HCPT NPs is a further prospective anticancer drug delivery system.
机译：首次提出了一种基于羧甲基纤维素（CMC）-熊果酸（UA）结合物的新型自组装纳米颗粒平台。通过将疏水性药物UA引入亲水性聚合物分子CMC中来合成CMC-UA共轭物，然后将另一种抗癌药物羟基喜树碱（HCPT）封装到该共轭物的自组装纳米颗粒（CMC-UA / HCPT NPs）中通过纳米沉淀法形成。所获得的纳米粒子具有合适的尺寸（约40 nm），高封装效率（HCPT约17.53 wt％）和载药效率（UA约29.62 wt％）。细胞实验表明，CMC–UA / HCPT NPs比游离UA和游离HCPT表现出更高的细胞毒性，这是由于血液保留时间比游离药物（UA的7.3倍，HCPT的2.5倍）更长且细胞吸收有效。 UA和HCPT的抗肿瘤能力，小鼠存活率和肿瘤生长抑制作用也很重要。此外，对副作用的评估清楚而详尽地证明了NPs可以大大降低超敏反应的风险。因此，CMC–UA / HCPT NP是进一步的前瞻性抗癌药物递送系统。

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