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Uncovering the action mechanism of polydatin via network pharmacological target prediction

机译：通过网络药理靶点预测揭示白藜芦醇苷的作用机理

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Polydatin (PD), a small natural compound originally extracted from Polygonum cuspidatum , exerts distinct biological functions in a variety of diseases. However, the action mechanism of PD has yet to be systematically explored. In this study, we firstly corroborated the druggability of PD by evaluating the medicinal properties of PD using a TCMSP server. We then conducted in silico target-prediction for PD using PharmMapper and ChemMapper, which led to the identification of 15 potential targets overlapping in both approaches. These 15 targets were subsequently evaluated by GeneMANIA, GO biological process and KEGG pathway analysis, which finally contribute to the construction of a drug-target-pathway network for PD. The network analysis revealed that these targets were mainly associated with cancer, cell growth and apoptosis, hormones and other physiological processes, outlining the pharmacological influences of PD on multiple integrated pathways involved in a particular network.
机译：Polydatin（PD）是最初从虎杖中提取的一种小型天然化合物，在多种疾病中具有独特的生物学功能。然而，PD的作用机理尚未系统地探索。在这项研究中，我们首先通过使用TCMSP服务器评估PD的药物特性来证实PD的可药用性。然后，我们使用PharmMapper和ChemMapper对PD进行了计算机模拟目标预测，从而确定了两种方法中重叠的15个潜在目标。随后通过GeneMANIA，GO生物学过程和KEGG通路分析对这15个靶标进行了评估，这些最终有助于构建PD的药物靶标-通路网络。网络分析表明，这些靶标主要与癌症，细胞生长和凋亡，激素和其他生理过程有关，概述了PD对涉及特定网络的多个整合途径的药理作用。

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