• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Hemocompatible poly(lactic acid) membranes prepared by immobilizing carboxylated graphene oxide via mussel-inspired method for hemodialysis
【24h】

Hemocompatible poly(lactic acid) membranes prepared by immobilizing carboxylated graphene oxide via mussel-inspired method for hemodialysis

机译：通过贻贝启发法固定化羧化氧化石墨烯的血液透析方法制备的血液相容性聚乳酸膜

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Poly(lactic acid) (PLA) is an environmentally friendly material, but the hydrophobicity and poor hemocompatibility of PLA impede its application as hemodialysis membranes. In this study, aiming to improve the hemocompatibility of PLA membranes, dopamine-g-carboxylated graphene oxide (DA-g-GOCOOH) was synthesized and then immobilized on PLA membranes via a mussel-inspired adhesion method. The effect of carboxyl content of graphene oxide on hemocompatibility was also investigated. Attenuated total reflectance Fourier transform infrared spectra (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) analysis confirmed that DA-g-GOCOOH was successfully immobilized on the PLA membranes. The significant improvement of hydrophilicity and electronegativity of the PLA membranes effectively alleviated the surface adhesion of platelets, prolonged the recalcification time and reduced the hemolysis ratio to less than 0.3%. Moreover, the DA-g-GOCOOH modified PLA membrane showed excellent dialysis performance, especially for the clearance of middle molecule toxin, which was up to 24%. The DA-g-GOCOOH immobilized layers were relatively stable after incubating in water. The present work demonstrated a potential way to improve the hemocompatibility of PLA membranes for hemodialysis.
机译：聚乳酸（PLA）是一种环保材料，但是PLA的疏水性和血液相容性差，阻碍了其作为血液透析膜的应用。本研究旨在提高PLA膜的血液相容性，合成了多巴胺- g -羧化氧化石墨烯（DA- g -GOCOOH），然后将其固定在PLA膜上< 通过贻贝启发的粘附方法。还研究了氧化石墨烯的羧基含量对血液相容性的影响。衰减全反射傅立叶变换红外光谱（ATR-FTIR），X射线光电子能谱（XPS）和扫描电子显微镜（SEM）分析证实DA- g -GOCOOH已成功固定在PLA膜上。 PLA膜的亲水性和电负性的显着改善有效地降低了血小板的表面粘附力，延长了重新钙化时间，并将溶血率降低至小于0.3％。此外，DA- g -GOCOOH改性的PLA膜表现出优异的透析性能，尤其是对中分子毒素的清除率高达24％。在水中孵育后，DA- g -GOCOOH固定化层相对稳定。目前的工作表明了一种潜在的方法来改善用于血液透析的PLA膜的血液相容性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号