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首页> 外文期刊>RSC Advances >Hemocompatible poly(lactic acid) membranes prepared by immobilizing carboxylated graphene oxide via mussel-inspired method for hemodialysis
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Hemocompatible poly(lactic acid) membranes prepared by immobilizing carboxylated graphene oxide via mussel-inspired method for hemodialysis

机译：通过使羧基化的石墨烯氧化物通过贻贝的血液透析方法固定羧化石墨烯氧化物制备的血液相选聚（乳酸）膜

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摘要

Poly(lactic acid) (PLA) is an environmentally friendly material, but the hydrophobicity and poor hemocompatibility of PLA impede its application as hemodialysis membranes. In this study, aiming to improve the hemocompatibility of PLA membranes, dopamine-g-carboxylated graphene oxide (DA-g-GOCOOH) was synthesized and then immobilized on PLA membranes via a mussel-inspired adhesion method. The effect of carboxyl content of graphene oxide on hemocompatibility was also investigated. Attenuated total reflectance Fourier transform infrared spectra (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) analysis confirmed that DA-g-GOCOOH was successfully immobilized on the PLA membranes. The significant improvement of hydrophilicity and electronegativity of the PLA membranes effectively alleviated the surface adhesion of platelets, prolonged the recalcification time and reduced the hemolysis ratio to less than 0.3%. Moreover, the DA-g-GOCOOH modified PLA membrane showed excellent dialysis performance, especially for the clearance of middle molecule toxin, which was up to 24%. The DA-g-GOCOOH immobilized layers were relatively stable after incubating in water. The present work demonstrated a potential way to improve the hemocompatibility of PLA membranes for hemodialysis.
机译：聚（乳酸）（PLA）是一种环保材料，但PLA的疏水性和差的血液相容性妨碍其应用作为血液透析膜。在该研究中，旨在改善PLA膜的血液相色，合成多巴胺-G-羧化的石墨烯（DA-G-GOCOOH），然后通过贻贝鼓励的粘附方法固定在PLA膜上。还研究了石墨烯氧化石墨烯含量对血液相色的影响。衰减全反射傅里叶变换红外光谱（ATR-FTIR），X射线光电子能谱（XPS）和扫描电子显微镜（SEM）分析证实，DA-G-GOCOOH被成功固定在PLA膜。 PLA膜的亲水性和电控性的显着提高有效地减轻了血小板的表面粘附，延长了重新持续时间并将溶血比降低至小于0.3％。此外，DA-G-GOCOOH改性PLA膜显示出优异的透析性能，特别是对于中间分子毒素的间隙，其高达24％。在水中温育后，DA-G-GOCOOH固定层相对稳定。本作者展示了改善血液透析PLA膜的血液相位性的潜在方法。

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  • 来源
    《RSC Advances》 |2018年第1期|共9页
  • 作者

    Ma Lankun; Huang Lilan; Zhang Yuzhong; Zhao Lizhi; Xin Qingping; Ye Hui; Li Hong;

  • 作者单位

    Tianjin Polytech Univ State Key Lab Separat Membranes &

    Membrane Proc Tianjin 300387 Peoples R China;

    Tianjin Polytech Univ State Key Lab Separat Membranes &

    Membrane Proc Tianjin 300387 Peoples R China;

    Tianjin Polytech Univ State Key Lab Separat Membranes &

    Membrane Proc Tianjin 300387 Peoples R China;

    Tianjin Polytech Univ State Key Lab Separat Membranes &

    Membrane Proc Tianjin 300387 Peoples R China;

    Tianjin Polytech Univ State Key Lab Separat Membranes &

    Membrane Proc Tianjin 300387 Peoples R China;

    Tianjin Polytech Univ State Key Lab Separat Membranes &

    Membrane Proc Tianjin 300387 Peoples R China;

    Tianjin Polytech Univ State Key Lab Separat Membranes &

    Membrane Proc Tianjin 300387 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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