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Chemical studies on the parasitic plant Thonningia sanguinea Vahl

机译：寄生植物Thonningia sanguinea Vahl的化学研究

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Thonningia sanguinea Vahl plays an important role in traditional medicine in many African cultures. A study of the n -hexane fraction of the whole plant of T. sanguinea led to the isolation of two glucocerebroside molecular species TSC-1 and TSC-2 , one β-sitosteryl-3β- D -glucopyranoside-6′- O -fatty acid ester molecular species, TSS-1 , and seven known triterpenes ( 1–7 ). The ethyl acetate fraction also afforded five known lignans ( 8–12 ) and one known flavanone ( 13 ). Their structures were elucidated by means of chemical and spectroscopic methods (methanolysis, NMR and mass spectrometry). Spectral analyses of the glucocerebrosides revealed mainly sphingosine-type ( TSC-1 ) and phytosphingosine-type ( TSC-2 ) cerebrosides, with both possessing mainly 2-hydroxy fatty acid and β- D -glucopyranose moieties. TSS-1 was found to be a β-sitosterol-type with fatty acid methyl esters and β- D -glucopyranoside moieties. The classes of compounds isolated from this plant are well known for their interesting biological activities including antimicrobial, antioxidant, anticancer, antiinflammatory and analgesic. They may therefore be responsible in part or in whole for these activities, hence validating the traditional uses of the plant. To the best of our knowledge, this is the first report on the isolation of all these compounds from T. sanguinea .
机译：非洲许多国家的传统医学中，Thunningia sanguinea Vahl发挥着重要作用。通过对红豆杉整个植物中正己烷成分的研究，可以分离出两种葡糖脑苷脂分子物种TSC-1和TSC-2，一种是β-谷甾醇基-3β-D-吡喃葡萄糖苷-6'-O-脂肪酸酯分子种类TSS-1和七个已知的三萜（1–7）。乙酸乙酯馏分还提供了五个已知的木脂素（8-12）和一个已知的黄烷酮（13）。通过化学和光谱方法（甲烷分解，NMR和质谱法）阐明了它们的结构。葡糖脑苷的光谱分析显示主要是鞘氨醇型（TSC-1）和植物鞘氨醇型（TSC-2）脑苷，两者均主要具有2-羟基脂肪酸和β-D-吡喃葡萄糖部分。发现TSS-1是具有脂肪酸甲酯和β-D-吡喃葡萄糖苷部分的β-谷甾醇型。从该植物中分离出的化合物种类以其有趣的生物学活性而闻名，包括抗菌剂，抗氧化剂，抗癌剂，抗炎药和镇痛药。因此，他们可能部分或全部负责这些活动，从而验证了植物的传统用途。据我们所知，这是首次从血红锥虫中分离出所有这些化合物的报道。

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