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首页> 外文期刊>RSC Advances >Near infrared dye loaded copper sulfide-apoferritin for tumor imaging and photothermal therapy
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Near infrared dye loaded copper sulfide-apoferritin for tumor imaging and photothermal therapy

机译：载有近红外染料的硫化铜-铁蛋白素用于肿瘤成像和光热疗法

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Development of photothermal agents for imaging-guided photothermal therapy (PTT) has been of great interest in the field of nanomedicine. CuS-apoferritin was prepared by a biomimetic synthesis method by using the inside cavity of apoferritin to control the size of CuS nanoparticles. Then, a water-soluble near infrared (NIR) dye (MBA) was bound with CuS-apoferritin, forming a nanocomplex (CuS-apoferritin-MBA) with greatly enhanced photothermal conversion efficiency compared to CuS-apoferritin. The unique optical behavior of CuS-apoferritin-MBA enables fluorescence imaging and photothermal therapy at separated optical wavelengths both, with optimized performances. CuS-apoferritin-MBA was then utilized as a photothermal agent for imaging-guided photothermal therapy in tumor-bearing mouse models. As revealed by in vivo fluorescence imaging, CuS-apoferritin-MBA showed high tumor uptake owing to an enhanced permeability and retention effect and the active targeting of apoferritin. In vivo photothermal therapy experiments indicated that tumors could be ablated by combining CuS-apoferritin-MBA with irradiation of an 808 nm laser. Thus, our work presents a safe, simple photothermal nanocomplex, promising for future clinical translation in cancer treatment.
机译：用于成像引导的光热疗法（PTT）的光热剂的开发在纳米医学领域中引起了极大的兴趣。通过仿生合成方法，利用脱铁铁蛋白的内腔来控制CuS纳米颗粒的尺寸，制备CuS-铁铁蛋白。然后，将水溶性近红外（NIR）染料（MBA）与CuS-apererritin结合，形成纳米复合物（CuS-apoferritin-MBA），与CuS-apoferritin相比，光热转换效率大大提高。 CuS-apererritin-MBA的独特光学性能使荧光成像和光热疗法都能在分离的光波长下进行，并具有最佳性能。然后，将CuS-apererritin-MBA用作光热剂，用于荷瘤小鼠模型中的成像引导光热疗法。如体内荧光成像所揭示，由于增强的通透性和保留作用以及载铁蛋白的主动靶向作用，CuS-apererritin-MBA显示出高的肿瘤吸收率。体内光热疗法实验表明，可以通过将CuS-apererritin-MBA与808 nm激光照射相结合来消融肿瘤。因此，我们的工作提出了一种安全，简单的光热纳米复合物，有望在癌症治疗中用于未来的临床翻译。

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