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Bamboo leaf-based carbon dots for efficient tumor imaging and therapy

机译：竹叶基碳点可实现有效的肿瘤成像和治疗

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In this study, carbon dots synthesized from bamboo leaf cellulose were used simultaneously as a staining agent and for doxorubicin delivery to target cancer cells. Owing to their nontoxic properties, the production of carbon dots from bamboo leaves is a green approach involving optimized application of bamboo tree waste. For multifunctional applications, the carbon dots were modified with 4-carboxybenzylboronic acid and doxorubicin to improve target specificity and drug delivery to HeLa tumor cells. The resulting modified carbon dots were characterized using different analytical techniques, which showed that they were biocompatible, nontoxic, and highly stable over a wide range of pH values and at high ionic strengths. Furthermore, in vitro confocal microscopy studies demonstrated their blue fluorescence and cellular pathway for entering HeLa cells via folate receptor-mediated endocytosis. Cell viability data and flow cytometry results also confirmed the selective uptake of the carbon dots by HeLa cells, which significantly enhanced cell cytotoxicity.
机译：在这项研究中，由竹叶纤维素合成的碳点同时用作染色剂，并用于将阿霉素递送至靶癌细胞。由于它们的无毒特性，从竹叶生产碳点是一种绿色方法，涉及优化利用竹树废料。对于多功能应用，碳点用4-羧基苄基硼酸和阿霉素修饰，以改善靶标特异性和药物向HeLa肿瘤细胞的递送。所得改性碳点使用不同的分析技术进行了表征，表明它们在广泛的pH值范围内和高离子强度下具有生物相容性，无毒且高度稳定。此外，体外共聚焦显微镜研究证明了它们的蓝色荧光和通过叶酸受体介导的内吞作用进入HeLa细胞的细胞途径。细胞活力数据和流式细胞仪结果也证实了HeLa细胞对碳点的选择性吸收，这大大增强了细胞的细胞毒性。

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