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首页> 外文期刊>RSC Advances >The similarity and variability of the iridoid glycoside profile and antioxidant capacity of aerial and underground parts of Lamiophlomis rotata according to UPLC-TOF-MS and multivariate analyses
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The similarity and variability of the iridoid glycoside profile and antioxidant capacity of aerial and underground parts of Lamiophlomis rotata according to UPLC-TOF-MS and multivariate analyses

机译：根据UPLC-TOF-MS和多变量分析法分析轮虫（Lamiophlomis rotata）的空中和地下部分的虹膜样糖苷谱和抗氧化能力的相似性和变异性

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摘要

Lamiophlomis rotata (L. rotata) is a Tibetan medicinal herb used for centuries that contains iridoid glycosides (IGs), which are pharmacologically active ingredients and can be used for quality control. The IG profiles of the underground and aerial parts of the plant were determined by UPLC-TOF-MS to evaluate the similarity and variability of the different herbal parts listed in the Chinese Pharmacopoeia. Twenty-six IGs were detected in the total ion current (TIC) profile of L. rotata, and twenty-two of these were identified by comparing the retention times and mass spectra of the compounds to those of authentic standards. Among these compounds, five IGs with the same molecular formula (C17H26O11) were identified for the first time by mass spectrometry based on their different hydroxyl group-substituted positions. The aerial part has a similar chemical profile to that of the roots. The difference between the two parts was determined by multivariate statistical analysis of the UPLC-TOF-MS data of 24 specimens. Sesamoside was explored as the most characteristic marker to distinguish the two parts of L. rotata. To further estimate the distinction between the two parts, the content of total IGs and the antioxidant capacity were investigated in samples from different locations. The aerial parts showed a high content of total IGs and high antioxidant capacity, although not higher than those of the roots. The results also suggest the dosage should be increased when the aerial parts are used as crude medicinal materials instead of the underground parts.
机译： Lamiophlomis rotata （ L。rotata ）是一种藏传草药，已有数百年的历史，它所含的鸢尾糖苷（IGs）是药理活性成分，可用于质量控制。通过UPLC-TOF-MS确定了植物地下和空中部分的IG分布，以评估《中国药典》中列出的不同草药部分的相似性和变异性。在 L的总离子流（TIC）曲线中检测到26个IG。通过比较化合物的保留时间和质谱图与真实标准品的鉴别，鉴定出其中的二十二种。在这些化合物中，五个具有相同分子式的IG（C 17 H 26 O 11 ）是基于它们的不同羟基取代位置首次通过质谱鉴定的。地上部分的化学特征与根部相似。通过对24个样本的UPLC-TOF-MS数据进行多元统计分析，确定了这两个部分之间的差异。芝麻红素被认为是区分 L的两个部分的最有特征的标记。旋转。为了进一步估计这两个部分之间的区别，在不同位置的样品中研究了总IG的含量和抗氧化能力。地上部分虽然不高于根部，但总IG含量高，抗氧化能力强。结果还表明，当将空中部分用作粗制药物而不是地下部分时，应增加剂量。

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