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首页> 外文期刊>RSC Advances >The similarity and variability of the iridoid glycoside profile and antioxidant capacity of aerial and underground parts of Lamiophlomis rotata according to UPLC-TOF-MS and multivariate analyses
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The similarity and variability of the iridoid glycoside profile and antioxidant capacity of aerial and underground parts of Lamiophlomis rotata according to UPLC-TOF-MS and multivariate analyses

机译：根据UPLC-TOF-MS和多变量分析的菱形甘油苷曲线和抗氧化物抗氧化物曲线和抗氧化能力的相似性和可变性

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摘要

Lamiophlomis rotata (L. rotata) is a Tibetan medicinal herb used for centuries that contains iridoid glycosides (IGs), which are pharmacologically active ingredients and can be used for quality control. The IG profiles of the underground and aerial parts of the plant were determined by UPLC-TOF-MS to evaluate the similarity and variability of the different herbal parts listed in the Chinese Pharmacopoeia. Twenty-six IGs were detected in the total ion current (TIC) profile of L. rotata, and twenty-two of these were identified by comparing the retention times and mass spectra of the compounds to those of authentic standards. Among these compounds, five IGs with the same molecular formula (C17H26O11) were identified for the first time by mass spectrometry based on their different hydroxyl group-substituted positions. The aerial part has a similar chemical profile to that of the roots. The difference between the two parts was determined by multivariate statistical analysis of the UPLC-TOF-MS data of 24 specimens. Sesamoside was explored as the most characteristic marker to distinguish the two parts of L. rotata. To further estimate the distinction between the two parts, the content of total IGs and the antioxidant capacity were investigated in samples from different locations. The aerial parts showed a high content of total IGs and high antioxidant capacity, although not higher than those of the roots. The results also suggest the dosage should be increased when the aerial parts are used as crude medicinal materials instead of the underground parts.
机译：Lamiophlomis rotata（L. Rotata）是一种用于几个世纪以来含有丝体糖苷（IGS）的藏药草，其是药理学活性成分，可用于质量控制。通过UPLC-TOF-MS确定地下和地下和天线部位的IG轮廓，以评估中国药典中列出的不同草药部分的相似性和变异性。在L. Rotata的总离子电流（TIC）曲线中检测到二十六个Ig，并通过将化合物的保留时间和质谱与原始标准的保留时间和质谱进行了鉴定了26个。在这些化合物中，基于其不同的羟基取代的位置，通过质谱法首次鉴定具有相同分子式（C17H26O11）的五个Ig。空中部分具有与根的类似化学曲线。两部分之间的差异是通过对24个样本的UPLC-TOF-MS数据的多变量统计分析来确定。 SESAMOSIDE被探索为最特征标记，以区分L. ROTATA的两部分。为了进一步估计两部分之间的区别，在不同地点的样品中研究了总Igs的含量和抗氧化能力。空中零件显示出高含量的IGS和高抗氧化能力，尽管不高于根部。结果还表明，当空中零件用作粗药物而不是地下部件时，应增加剂量。

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  • 来源
    《RSC Advances》 |2018年第5期|共10页
  • 作者

    Zhang Dan; Gao Yun-ling; Jiang Sheng; Chen Yiwen; Zhang Yi; Pan Zheng;

  • 作者单位

    Chongqing Med Univ Coll Tradit Chinese Med Chongqing Peoples R China;

    Chongqing Inst Posts &

    Telecommun Sch Bioinformat Chongqing Peoples R China;

    Chongqing Inst Food &

    Drug Control Chongqing Peoples R China;

    Chongqing Inst Posts &

    Telecommun Sch Bioinformat Chongqing Peoples R China;

    Chengdu Univ Tradit Chinese Med Coll Ethn Med Chengdu Sichuan Peoples R China;

    Chongqing Med Univ Coll Tradit Chinese Med Chongqing Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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