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首页> 外文期刊>RSC Advances >Biofunctionalized and self-supported polypyrrole frameworks as nanostructured ECM-like biointerfaces
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Biofunctionalized and self-supported polypyrrole frameworks as nanostructured ECM-like biointerfaces

机译：生物功能化和自支撑的聚吡咯骨架，如纳米结构的ECM样生物界面

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Hybrid nanobiointerfaces were designed as an original contribution to the challenge of synthesizing nanostructured biomaterials integrating a set of cell fate-determining cues, originally provided to cells by the extracellular matrix (ECM). The produced biointerfaces consist of a stiff framework of intersected polypyrrole (PPy) nanotubes supporting a soft multilayer composed of ECM-derived biomacromolecules: collagen (Col) and hyaluronic acid (HA). PPy frameworks with highly tunable characteristics were synthesized through chemical oxidative polymerization of pyrrole monomers, templated within track-etched polycarbonate (PC) membranes featuring a network of intersected nanopores. PPy interfaces with a porosity of 80%, composed of nanotubes with an average diameter ranging from 40 to 300 nm, intersecting at an angle of 90°, were shown to be self-supported. These rigid PPy nanostructured interfaces were functionalized with a self-assembling (HA/Col) multilayer deposited via a layer-by-layer process. Biofunctionalized and unmodified PPy frameworks were both shown to promote sustained cell adhesion, therefore demonstrating the cytocompatibility of the engineered matrices. Such nanobiointerfaces, combining a mechanically-stable framework of tunable dimensions with a soft biopolymeric multilayer of highly versatile nature, pave the way towards cell-instructive biomaterials able to gather a wide range of cues guiding cell behavior. The developed self-supported structures could be used as a coating or as membranes bridging different tissues.
机译：杂交纳米生物界面被设计为对合成纳米结构生物材料的挑战做出了最初的贡献，该材料整合了一组细胞命运决定线索，这些线索最初是由细胞外基质（ECM）提供给细胞的。产生的生物界面由相交的聚吡咯（PPy）纳米管的刚性框架组成，该框架支撑着由ECM衍生的生物大分子：胶原（Col）和透明质酸（HA）组成的柔软多层。通过吡咯单体的化学氧化聚合合成具有高度可调特性的PPy骨架，该模板在以相交纳米孔网络为特征的轨迹蚀刻聚碳酸酯（PC）膜中进行模板化。孔隙率为80％的PPy界面是自支撑的，该界面由平均直径为40到300 nm的纳米管组成，相交的角度为90°。这些刚性的PPy纳米结构界面通过通过逐层工艺沉积的自组装（HA / Col）多层进行了功能化。生物功能化和未修饰的PPy框架均显示出可促进持续的细胞粘附，因此证明了工程基质的细胞相容性。此类纳米生物界面将可调尺寸的机械稳定框架与具有高度通用性的柔软生物聚合物多层相结合，为开发能够收集各种指导细胞行为线索的细胞指导性生物材料铺平了道路。发达的自支撑结构可以用作覆盖不同组织的涂层或膜。

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