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首页> 外文期刊>RSC Advances >Inhibition of H1N1 influenza virus by selenium nanoparticles loaded with zanamivir through p38 and JNK signaling pathways
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Inhibition of H1N1 influenza virus by selenium nanoparticles loaded with zanamivir through p38 and JNK signaling pathways

机译：负载扎那米韦的硒纳米颗粒通过p38和JNK信号通路抑制H1N1流感病毒

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Zanamivir is an effective drug for influenza virus infection, but strong molecular polarity and aqueous solubility limit its clinical application. In recent years, selenium nanoparticles (SeNPs) have attracted attention in the biological field. In this study, surface decoration of SeNPs using zanamivir (ZNV) with antiviral properties was demonstrated. SeNPs co-delivery of a zanamivir nanosystem was designed to reverse influenza virus infection. In breif, the MTT assay, cytopathic effect and nucleic acid level of the virus suggested that zanamivir modified SeNPs (Se@ZNV) resisted proliferation of H1N1 virus and MDCK cells achieved higher viability after treatment with this compound. Besides, both activation and expression of caspase-3 induced during H1N1 virus infection were depressed when treated with Se@ZNV. Furthermore, phosphorylation of p38 and JNK were down-regulated by Se@ZNV. Taken together, our study indicates that Se@ZNV is a novel promising pharmaceutical against H1N1 influenza virus infection.
机译：扎那米韦是一种有效的流感病毒感染药物，但是强分子极性和水溶性限制了其临床应用。近年来，硒纳米颗粒（SeNPs）在生物领域引起了关注。在这项研究中，证明了使用具有抗病毒特性的扎那米韦（ZNV）对SeNPs进行表面修饰。扎那米韦纳米系统的SeNPs共交付旨在逆转流感病毒感染。在Breif中，MTT分析，病毒的细胞病变作用和核酸水平表明，扎那米韦修饰的SeNPs（Se @ ZNV）抵抗H1N1病毒的增殖，用该化合物处理后MDCK细胞获得更高的生存力。此外，当用Se @ ZNV处理时，H1N1病毒感染期间诱导的caspase-3的激活和表达均降低。此外，Se @ ZNV下调了p38和JNK的磷酸化。综上所述，我们的研究表明，Se @ ZNV是一种针对H1N1流感病毒感染的新型有前途的药物。

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