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首页> 外文期刊>RSC Advances >Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating
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Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating

机译：通过流化床涂层改善泡腾系统的粘附性，吸湿性和致密性

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摘要

Recently, effervescent tablets (ETs) have become increasingly popular with patients in clinics due to their fast disintegration by acid–alkali reactions in water. However, certain undesirable properties of ETs ( e.g. , sticking and high hygroscopicity) can limit their production and application. In particular, frequent sticking always severely decreases the tablet quality and productivity. Therefore, in this study, polyvinylpyrrolidone (PVP) at different usage levels, grades, or spray solution concentrations was coated onto the surfaces of both acidic and alkaline granules of ETs by means of the fluid-bed coating technique. In terms of fully characterized powder, tableting, and tablet properties, the following points were concluded: (i) a uniform coating of PVP onto the surfaces of these two granules not only resolved the sticking problem, but also effectively decreased the hygroscopicity and enhanced the compactibility; (ii) the improvements increased with an increase in the PVP content or PVP molecular weight and a decrease in the PVP spray solution concentration owing to the formation of an increasingly even and cohesive coating layer; (iii) the process of fluid-bed coating was not the simple superposition or simple mixing of two different materials' properties; (iv) the coating process did not cause significant influences on the disintegration time of ETs. Overall, it is fairly meaningful to further promote the development of ETs in practice since these problems have been overcome.
机译：最近，由于泡腾片（ETs）由于在水中的酸碱反应而迅速崩解，因此在临床上越来越受患者欢迎。但是，ET的某些不良特性（例如，粘附和高吸湿性）会限制其生产和应用。特别是，频繁粘贴总是会严重降低片剂的质量和生产率。因此，在这项研究中，通过流化床包衣技术将不同用量，等级或喷雾溶液浓度的聚乙烯吡咯烷酮（PVP）涂在ETs的酸性和碱性颗粒表面上。就完全表征的粉末，压片和片剂性质而言，得出以下几点：（i）在这两个颗粒表面均匀地涂覆PVP，不仅解决了粘附问题，而且有效地降低了吸湿性并增强了致密性（ii）由于PVP含量或PVP分子量的增加和PVP喷雾溶液浓度的降低，由于形成了越来越均匀和粘结性的涂层而使改进增加; （iii）流化床涂覆的过程不是两种不同材料特性的简单叠加或简单混合; （iv）包衣过程对ET的崩解时间没有显着影响。总体而言，由于已克服了这些问题，因此在实践中进一步促进ET的发展非常有意义。

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