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Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating

机译：通过液体床涂层粘附，吸湿性和泡腾系统的可粘附性和可调性的改进

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Recently, effervescent tablets (ETs) have become increasingly popular with patients in clinics due to their fast disintegration by acid-alkali reactions in water. However, certain undesirable properties of ETs (e.g., sticking and high hygroscopicity) can limit their production and application. In particular, frequent sticking always severely decreases the tablet quality and productivity. Therefore, in this study, polyvinylpyrrolidone (PVP) at different usage levels, grades, or spray solution concentrations was coated onto the surfaces of both acidic and alkaline granules of ETs by means of the fluid-bed coating technique. In terms of fully characterized powder, tableting, and tablet properties, the following points were concluded: (i) a uniform coating of PVP onto the surfaces of these two granules not only resolved the sticking problem, but also effectively decreased the hygroscopicity and enhanced the compactibility; (ii) the improvements increased with an increase in the PVP content or PVP molecular weight and a decrease in the PVP spray solution concentration owing to the formation of an increasingly even and cohesive coating layer; (iii) the process of fluid-bed coating was not the simple superposition or simple mixing of two different materials' properties; (iv) the coating process did not cause significant influences on the disintegration time of ETs. Overall, it is fairly meaningful to further promote the development of ETs in practice since these problems have been overcome.
机译：最近，由于它们在水中的酸性碱反应的快速崩解，泡腾片（ETS）越来越受临床患者越来越受欢迎。然而，ETS（例如，粘附和高吸湿性）的某些不希望的性能可以限制其生产和应用。特别是，频繁的粘性总是严重降低平板电脑质量和生产率。因此，在本研究中，通过流体床涂布技术将不同使用水平，等级或喷雾溶液浓度的聚乙烯吡咯烷酮（PVP）涂覆到ETS的两种酸性和碱性颗粒的表面上。就完全表征的粉末，压片和片剂性质而言，结束了以下几点：（i）将PVP均匀涂布到这两个颗粒的表面上不仅解决了粘性问题，而且还有效地降低了吸湿性并增强了紧缩; （ii）随着PVP含量或PVP分子量的增加而增加，由于形成越来越均匀涂层的PVP喷雾溶液浓度，PVP喷雾溶液浓度的降低增加; （iii）流体床涂层的过程不是两种不同材料的简单叠加或简单混合; （iv）涂层方法对ETS的崩解时间没有造成显着影响。总的来说，在实践中进一步促进ETS的发展是相当有意义的，因为这些问题得到了克服。

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    《RSC Advances》 |2019年第54期|共15页
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  • 正文语种 eng
  • 中图分类 化学;
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