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首页> 外文期刊>RSC Advances >Enhancement of neural stem cell survival, proliferation and differentiation by IGF-1 delivery in graphene oxide-incorporated PLGA electrospun nanofibrous mats
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Enhancement of neural stem cell survival, proliferation and differentiation by IGF-1 delivery in graphene oxide-incorporated PLGA electrospun nanofibrous mats

机译：在掺入氧化石墨烯的PLGA电纺纳米纤维垫中通过IGF-1传递增强神经干细胞的存活，增殖和分化

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The mammalian central nervous system has a limited ability for self-repair under injury conditions. The treatment of nerve injuries has been revolutionised with the development of tissue engineering techniques. However, the lack of bioactivity has severely restricted the application of biodegradable implants for neurogenesis. Therefore, surface modification of biomaterials is crucial to improve their bioactivity and promote endogenous repair mechanisms for nerve regeneration. Insulin-like growth factor 1 (IGF-1) is a growth factor for neuroprotection and neurogenesis. In this study, IGF-1 was successfully immobilised on graphene oxide (GO)-incorporated poly(lactic- co -glycolic acid) (PLGA) biodegradable electrospun nanofibres. For the in vitro investigation, neural stem cells (NSCs) were cultured on different nanofibres to observe various cellular activities. GO enhanced NSC survival under H _(2) O _(2) pre-treatment and neuronal differentiation to some extent. More importantly, the immobilisation of IGF-1 onto the PLGA/GO nanofibres resulted in significantly increased NSC survival, proliferation, and differentiation. Findings from this study revealed that using PLGA/GO electrospun nanofibres to immobilise IGF-1 has excellent potential for the enhancement of the neuroprotective and neurogenic effects of nerve implants.
机译：哺乳动物中枢神经系统在受伤情况下自我修复的能力有限。随着组织工程技术的发展，神经损伤的治疗方式发生了革命性的变化。但是，缺乏生物活性严重限制了可生物降解植入物在神经发生中的应用。因此，生物材料的表面改性对于提高其生物活性和促进神经再生的内源性修复机制至关重要。胰岛素样生长因子1（IGF-1）是神经保护和神经发生的生长因子。在这项研究中，IGF-1成功地固定在掺入氧化石墨烯（GO）的聚乳酸-乙醇酸（PLGA）可生物降解的电纺纳米纤维上。为了进行体外研究，将神经干细胞（NSC）培养在不同的纳米纤维上以观察各种细胞活性。 GO在H _（2）O _（2）预处理和神经元分化下可提高NSC存活率。更重要的是，将IGF-1固定在PLGA / GO纳米纤维上可显着提高NSC的存活，增殖和分化。这项研究的发现表明，使用PLGA / GO电纺纳米纤维固定IGF-1具有增强神经植入物的神经保护和神经源性作用的巨大潜力。

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