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Graphene oxide-based electrochemical activation of ethionamide towards enhanced biological activity

机译：乙酰胺基于氧化石墨烯的电化学活化以增强生物活性

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The electrochemical behavior of ethionamide (ETO) was investigated on GO (～500 nm) using the linear sweep voltammetric (LSV) technique at the sweep rate of 10 mV s ~(?1) in 1 M PBS buffer solution, and the characteristic anodic signal was examined at 0.240 V over the potential range of ?0.4 to 1 V vs. SCE. However, linearity was observed with the increase in scan rate (2–300 mV s ~(?1) ) and concentration of ETO (1 μM to 100 mM), suggesting that the process involved diffusion-controlled electron transfer. The results also exhibited excellent current and potential stability, limit of detection (LOD 1.33) and limit of quantification (LOQ 4.4) at optimized experimental conditions. This electrochemical oxidation method was successfully applied in the complete oxidation of ETO to its oxidized form, which was further confirmed by high resolution mass spectroscopy (HRMS) and Fourier transform infrared (FTIR) spectroscopic measurements. Interestingly, the comparative biological evaluation of ETO and ETO-O (oxidised form) showed good enhancement in the activity of oxidised ETO against some Gram-negative pathogens, such as E. aerogenes , S. abony , S. boydii , and E. coli .
机译：使用线性扫描伏安法（LSV）在1 M PBS缓冲溶液中的扫描速率为10 mV s〜（？1）的条件下，在GO（〜500 nm）上研究了乙硫酰胺（ETO）的电化学行为。相对于SCE，在±0.4至1 V的电位范围内，以0.240 V检查信号。然而，随着扫描速率（2-300 mV s〜（？1））和ETO浓度（1μM至100 mM）的增加，观察到线性关系，这表明该过程涉及扩散控制的电子转移。结果还显示出优异的电流和电位稳定性，在优化的实验条件下的检测限（LOD 1.33）和定量限（LOQ 4.4）。这种电化学氧化方法已成功应用于ETO的完全氧化成其氧化形式，这已通过高分辨率质谱（HRMS）和傅立叶变换红外（FTIR）光谱测量进一步证实。有趣的是，对ETO和ETO-O（氧化形式）的比较生物学评估显示，氧化ETO对某些革兰氏阴性病原体（如产气链球菌，S。abony，S。boydii和大肠杆菌）的活性增强。 。

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