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Graphene oxide-based electrochemical activation of ethionamide towards enhanced biological activity

机译：基于石墨烯基氧化物的乙酰胺电化学激活增强生物活性

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The electrochemical behavior of ethionamide (ETO) was investigated on GO (similar to 500 nm) using the linear sweep voltammetric (LSV) technique at the sweep rate of 10 mV s(-1) in 1 M PBS buffer solution, and the characteristic anodic signal was examined at 0.240 V over the potential range of -0.4 to 1 V vs. SCE. However, linearity was observed with the increase in scan rate (2-300 mV s(-1)) and concentration of ETO (1 mu M to 100 mM), suggesting that the process involved diffusion-controlled electron transfer. The results also exhibited excellent current and potential stability, limit of detection (LOD 1.33) and limit of quantification (LOQ 4.4) at optimized experimental conditions. This electrochemical oxidation method was successfully applied in the complete oxidation of ETO to its oxidized form, which was further confirmed by high resolution mass spectroscopy (HRMS) and Fourier transform infrared (FTIR) spectroscopic measurements. Interestingly, the comparative biological evaluation of ETO and ETO-O (oxidised form) showed good enhancement in the activity of oxidised ETO against some Gram-negative pathogens, such as E. aerogenes, S. abony, S. boydii, and E. coli.
机译：在1M PBS缓冲溶液中的10mV S（-1）的扫描速率下，使用线性扫描伏安（LSV）技术对乙酰胺（EtO）的电化学行为进行研究（类似​​于500nm），以及在1M PBS缓冲溶液中的扫描速率和特征阳极信号在0.240 V的0.0.4至1V与SCE的电位范围内检查。然而，随着扫描速率的增加（2-300mV S（-1））和EtO的浓度（1μm至100mm）的浓度，观察到线性度，表明该过程涉及扩散控制的电子转移。结果还表现出优异的电流和潜在稳定性，检测极限（LOD 1.33）和定量限制（LOQ 4.4）在优化的实验条件下。该电化学氧化方法成功地应用于EtO的完全氧化成其氧化形式，其通过高分辨率质谱（HRMS）和傅里叶变换红外（FTIR）光谱测量进一步证实。有趣的是，EtO和EtO-O（氧化形式）的比较生物学评价显示出氧化ento的良好增强，氧化eTO对一些革兰氏阴性病原体，例如E. Aerogenes，S. Abony，S. Boydii和大肠杆菌。

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    《RSC Advances》 |2019年第61期|共10页
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  • 正文语种 eng
  • 中图分类 化学;
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