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A chemodosimeter-modified carbon nanotube-field effect transistor: toward a highly selective and sensitive electrical sensing platform

机译：化学计量仪修饰的碳纳米管场效应晶体管：朝向高度选择性和灵敏的电传感平台

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摘要

We present a carbon nanotube-field effect transistor (CNT-FET) biosensor which first implements the chemodosimeter sensing principle in CNT nanoelectronics. We experimentally illustrate the specific molecular interplay that the cysteine-selective chemodosimeter immobilized on the CNT surface can specifically interact with cysteine, which leads to the chemical transformation of the chemodosimeter. Since the chemical transformation of the chemodosimeter can disrupt the charge distribution in the vicinity of the CNT surface, the carrier equilibrium in CNT might be altered, and manifested by the conductivity change of CNT-FET. The real-time conductance measurements show our biosensor is capable of label-free, rapid, highly selective and ultrasensitive detection of cysteine with a detection limit down to 0.45 fM. These results first verify the signaling principle competency of chemical transformation of the chemodosimeter in CNT electronic sensors. Combined with the advantages of the highly selective chemodosimeter and sensitive CNT-FET, the excellent performance of our sensor indicates its promising prospect as a valuable tool for developing highly sensitive and selective sensing platforms in practical application.
机译：我们提出了一种碳纳米管场效应晶体管（CNT-FET）生物传感器，该传感器首先在CNT纳米电子学中实现了化学计量传感器的原理。我们实验性地说明了固定在CNT表面的半胱氨酸选择性化学计量仪可以与半胱氨酸特异性相互作用的特定分子相互作用，这导致化学计量仪的化学转化。由于化学计量仪的化学转变会破坏CNT表面附近的电荷分布，因此CNT中的载流子平衡可能会发生变化，并通过CNT-FET的电导率变化体现出来。实时电导测量表明，我们的生物传感器能够无标记，快速，高度选择性和超灵敏地检测半胱氨酸，检测限低至0.45 fM。这些结果首先验证了化学计量仪在CNT电子传感器中化学转化的信号传导原理能力。结合高选择性化学计量仪和灵敏的CNT-FET的优点，我们传感器的出色性能表明其作为在实际应用中开发高灵敏和选择性传感平台的有价值的工具具有广阔的前景。

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