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A chemodosimeter-modified carbon nanotube-field effect transistor: toward a highly selective and sensitive electrical sensing platform

机译:化学倍细值改性碳纳米管场效应晶体管:朝向高度选择性和敏感的电感平台

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We present a carbon nanotube-field effect transistor (CNT-FET) biosensor which first implements the chemodosimeter sensing principle in CNT nanoelectronics. We experimentally illustrate the specific molecular interplay that the cysteine-selective chemodosimeter immobilized on the CNT surface can specifically interact with cysteine, which leads to the chemical transformation of the chemodosimeter. Since the chemical transformation of the chemodosimeter can disrupt the charge distribution in the vicinity of the CNT surface, the carrier equilibrium in CNT might be altered, and manifested by the conductivity change of CNT-FET. The real-time conductance measurements show our biosensor is capable of label-free, rapid, highly selective and ultrasensitive detection of cysteine with a detection limit down to 0.45 fM. These results first verify the signaling principle competency of chemical transformation of the chemodosimeter in CNT electronic sensors. Combined with the advantages of the highly selective chemodosimeter and sensitive CNT-FET, the excellent performance of our sensor indicates its promising prospect as a valuable tool for developing highly sensitive and selective sensing platforms in practical application.
机译:我们提出了一种碳纳米管场效应晶体管(CNT-FET)生物传感器,其首先在CNT纳米电子中实现ChemodoImeter感测原理。我们通过实验说明了固定在CNT表面上的半胱氨酸选择性化学计的特定分子相互作用表可以与半胱氨酸特异性相互作用,这导致化学计量计的化学转化。由于化学计量计的化学转化可以破坏CNT表面附近的电荷分布,因此CNT中的载体平衡可能会被改变,并且通过CNT-FET的电导率变化表现出。实时电导测量表明我们的生物传感器能够无标记,快速,高度选择性和超细敏感的半胱氨酸,检测限为0.45 fm。这些结果首先验证了CNT电子传感器中化学计量计的化学转换的信号原理竞争力。结合高选择性化学倍细计和敏感的CNT-FET的优点,我们的传感器的优异性能表示其希望是在实际应用中开发高度敏感和选择性传感平台的宝贵工具。

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    《RSC Advances》 |2019年第49期|共7页
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  • 正文语种 eng
  • 中图分类 化学;
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