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Pseudonectrins A–D, heptaketides from an endophytic fungus Nectria pseudotrichia

机译:假牙菌素A–D,内生真菌Neptria pseudotrichia的七肽

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Four new heptaketides, pseudonectrins A–D ( 1–4 ), and four known compounds ( 5–8 ) were isolated from cultures of an endophytic fungus Nectria pseudotrichia . Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1–3 and 4 were assigned by electronic circular dichroism calculations and the modified Mosher method, respectively. Compound 1–3 showed moderate cytotoxicity, with IC _(50) values of 11.6–41.2 μM.
机译:从内生真菌伪拟南芥的培养物中分离出四个新的七肽,假菌素A–D(1-4)和四个已知化合物(5–8)。主要通过NMR实验阐明了它们的结构。 1-3和4的绝对构型分别通过电子圆二色性计算和改进的Mosher方法指定。化合物1-3显示出中等的细胞毒性,IC _(50)值为11.6-41.2μM。

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