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New portable smartphone-based PDMS microfluidic kit for the simultaneous colorimetric detection of arsenic and mercury

机译：基于便携式智能手机的新型PDMS微流控套件，用于同时比色检测砷和汞

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A smartphone-based microfluidic platform was developed for point-of-care (POC) detection using surface plasmon resonance (SPR) of gold nanoparticles (GNPs). The simultaneous colorimetric detection of trace arsenic and mercury ions (As ~(3+) and Hg ~(2+) ) was performed using a new image processing application (app). To achieve this goal, a microfluidic kit was fabricated using a polydimethylsiloxane (PDMS) substrate with the configuration of two separated sensing regions for the quantitative measurement of the color changes in GNPs to blue/gray. To fabricate the microfluidic kit, a Plexiglas mold was cut using a laser based on the model obtained from AutoCAD and Comsol outputs. The colorimetric signals originated from the formation of nanoparticle aggregates through the interaction of GNPs with dithiothreitol – 10,12-pentacosadiynoic acid (DTT-PCDA) and lysine (Lys) in the presence of As ~(3+) and Hg ~(2+) ions. This assembly exhibited the advantages of simplicity, low cost, and high portability along with a low volume of reagents and multiplex detection. Heavy Metals Detector (HMD), as a new app for the RGB reader, was programmed for an Android smartphone to quantify colorimetric analyses. Compared with traditional image processing, this app provided significant improvements in sensitivity, time of analysis, and simplicity because the color intensity is measured through a new normalization equation by converting RGB to an Integer system. As a simple, real-time, and portable analytical kit, the fabricated sensor could detect low concentrations of As ~(3+) (710 to 1278 μg L ~(?1) ) and Hg ~(2+) (10.77 to 53.86 μg L ~(?1) ) ions in water samples at ambient conditions.
机译：开发了基于智能手机的微流体平台，用于使用金纳米颗粒（GNP）的表面等离子体共振（SPR）进行即时检测（POC）。使用新的图像处理应用程序（app）同时进行比色检测痕量的砷和汞离子（As〜（3+）和Hg〜（2+））。为了实现此目标，使用聚二甲基硅氧烷（PDMS）基板制作了微流体试剂盒，该基板具有两个分离的感应区域，用于定量测量GNP变为蓝色/灰色的颜色。为了制造微流体套件，根据从AutoCAD和Comsol输出获得的模型，使用激光切割有机玻璃模具。比色信号起源于GNPs与二硫苏糖醇– 10,12-戊二十二碳二烯酸（DTT-PCDA）和赖氨酸（Lys）在As〜（3+）和Hg〜（2+ ）离子。该组件显示出简单，低成本，高便携性以及少量试剂和多重检测的优点。重金属检测器（HMD）作为RGB阅读器的新应用程序，已针对Android智能手机进行了编程，以定量比色分析。与传统的图像处理相比，此应用程序在灵敏度，分析时间和简单性方面均提供了显着改进，因为通过将RGB转换为Integer系统通过新的归一化方程来测量色彩强度。作为一种简单，实时，便携式的分析套件，该传感器可以检测低浓度的As〜（3+）（710至1278μgL〜（？1））和Hg〜（2+）（10.77至53.86环境条件下水样品中的微克L〜（？1）离子。

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