Iodine-mediated C–N and N–N bond formation: a facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions

Geeta Sai Mani; Kavitha Donthiboina; Siddiq Pasha Shaik; Nagula Shankaraiah; Ahmed Kamal

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Iodine-mediated C–N and N–N bond formation: a facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions

机译：碘介导的C–N和N–N键的形成：一种在无金属和无叠氮条件下简便地一锅合成1,2,3-三唑的方法

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A novel strategy towards the synthesis of 1,4-disubstituted 1,2,3-triazoles via C–N and N–N bond formation has been demonstrated under transition metal-free and azide-free conditions. These 1,2,3-triazoles were obtained in a regioselective manner from commercially available anilines, aryl alkenes/aryl alkynes and N -tosylhydrazines using I _(2) under O _(2) atmosphere. Broad substrate scope, milder reaction conditions, good to moderate yields and clean protocol are the notable features of the method. Moreover, this protocol is amenable for the generation of a library of medicinally important key building blocks.

机译：在无过渡金属和无叠氮化物的条件下，已经证明了通过C–N和N–N键的形成合成1,4-二取代1,2,3-三唑的一种新策略。这些1,2,3-三唑以区域选择性的方式在I_（2）气氛下使用I_（2）从市售苯胺，芳基烯烃/芳基炔烃和N-甲苯磺酰基肼获得。该方法的显着特点是底物范围广，反应条件温和，收率中等至中等，操作规程纯正。此外，该协议适用于生成医学上重要的重要构建模块库。

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《RSC Advances》 |2019年第46期|共11页
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Geeta Sai Mani; Kavitha Donthiboina; Siddiq Pasha Shaik; Nagula Shankaraiah; Ahmed Kamal;
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1. Iodine-mediated C-N and N-N bond formation: a facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions [J] . RSC Advances . 2019,第46期

机译：碘介导的C-N和N-N键形成：在无金属和无叠氮的条件下的1,2,3-三唑的容易一罐合成方法
2. Iodine-mediated C–N and N–N bond formation: a facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions [J] . Geeta Sai Mani, Kavitha Donthiboina, Siddiq Pasha Shaik, RSC Advances . 2019,第46期

机译：碘介导的C–N和N–N键的形成：一种在无金属和无叠氮条件下简便地一锅合成1,2,3-三唑的方法
3. Aerobic Oxidative Cycloaddition of alpha-Chlorotosylhydrazones with Arylamines: General Chemoselective Construction of 1,4-Disubstituted and 1,5-Disubstituted 1,2,3-Triazoles under Metal-Free and Azide-Free Conditions [J] . Bai Hui-Wen, Cai Zhong-Jian, Wang Shun-Yi, Organic letters . 2015,第12期

机译：α-氯代磺酰hydr与芳胺的好氧氧化环加成反应：无金属和无叠氮条件下1,4-二取代和1,5-二取代的1,2,3-三唑的一般化学选择性结构
4. Copper(II) Triflate as a Double Catalyst for the One-Pot Click Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Benzylic Acetates [C] . Eiji Shimizu, Satoshi Kikuchi, Shin-ichi Fnkuzawa Symposium on Organometallic Chemistry . 2007

机译：铜（II）作为单罐的双催化剂，单击1,4-二取代的1,2,3-三唑的双催化剂，从苄基乙酸盐中键合
5. 1,2,3-triazoles as X-factor in gold(I) activation of challenging C-C triple bond transformations. [D] . Wang, Qiaoyi. 2014

机译：1,2,3-三唑作为X因子在具有挑战性的C-C三键转化的金（I）活化中。
6. Facile synthesis of 1H-imidazo12-bpyrazoles via a sequential one-pot synthetic approach [O] . András Demjén, Márió Gyuris, János Wölfling, 2014

机译：通过顺序一锅合成法轻松合成1H-咪唑并12-b吡唑
7. Nano-cuprous oxide catalyzed one-pot synthesis of a carbazole-based STAT3 inhibitor: a facile approach via intramolecular C-N bond formation reactions [O] . Baburajeev, C. P., Mohan, C. D., Patil, G. S., 2016

机译：纳米氧化亚铜催化一锅合成咔唑基STAT3抑制剂：通过分子内C-N键形成反应的简便方法
8. The Crystal and Molecular Structure of 2-Phenyl-4,5-Dianilino-2H-1,2,3-Triazole; Correlation between the Asymmetry of the Triazole Ring and the Conformations of the Anilino Substituents [R] . Harlow, R. L., Brown, S. B., Dewar, M. J. S., 1976

机译：2-苯基-4,5-二苯胺基-2H-1,2,3-三唑的晶体和分子结构;三唑环的不对称性与苯胺基取代基构象的相关性

Iodine-mediated C–N and N–N bond formation: a facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions

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