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首页> 外文期刊>RSC Advances >The anti-diarrhea activity of red algae-originated sulphated polysaccharides on ETEC-K88 infected mice
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The anti-diarrhea activity of red algae-originated sulphated polysaccharides on ETEC-K88 infected mice

机译：红藻源硫酸盐多糖对ETEC-K88感染小鼠的腹泻活性

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Polysaccharides from red algae Porphyra haitanensis and Gracilaria lemaneiformis possess various bioactive functions, however, their anti-diarrhea activity remains incompletely defined. In the current study, sulphated polysaccharides were extracted by high pressure treatment plus ethanol precipitation from these two algae, and named PHSP _((hp)) and GLSP _((hp)) , respectively. PHSP _((hp)) and GLSP _((hp)) showed decreased viscosity and molecular weight. Meanwhile, they have a certain immunomodulatory effect on wound healing and migration of RAW264.7 cells. Moreover, they significantly increased the secretion of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). A BALB/c model infected by enterotoxigenic Escherichia coli (ETEC)-K88 was also established to evaluate the anti-diarrhea activity of PHSP _((hp)) and GLSP _((hp)) . The results showed that PHSP _((hp)) and GLSP _((hp)) were able to alleviate mice diarrhea symptoms. Meanwhile, they inhibited the release of pro-inflammatory cytokines and suppressed the secretion of immunoglobulin A via reducing the population of B cells. In addition, the nitroblue tetrazolium levels of mouse serum were decreased. Taken together, PHSP _((hp)) and GLSP _((hp)) alleviated the inflammatory response of ETEC-K88-induced diarrhea through both specific and non-specific immunity. Sulphated polysaccharides from red algae may be used as functional food components for remitting diarrhea.
机译：红藻海藻紫菜（Porphyra haitanensis）和Lecileiformis的多糖具有多种生物活性功能，但其抗腹泻活性仍未完全定义。在本研究中，通过高压处理加上乙醇沉淀从这两种藻类中提取了硫酸化多糖，分别命名为PHSP _（（hp））和GLSP _（（hp））。 PHSP _（（hp））和GLSP _（（hp））的粘度和分子量降低。同时，它们对RAW264.7细胞的伤口愈合和迁移具有一定的免疫调节作用。此外，它们显着增加促炎性细胞因子肿瘤坏死因子-α（TNF-α）和白介素-6（IL-6）的分泌。还建立了由肠毒素大肠杆菌（ETEC）-K88感染的BALB / c模型，以评估PHSP _（（hp））和GLSP _（（hp））的抗腹泻活性。结果表明，PHSP _（（hp））和GLSP _（（hp））能够缓解小鼠的腹泻症状。同时，它们通过减少B细胞的数量来抑制促炎性细胞因子的释放并抑制免疫球蛋白A的分泌。另外，小鼠血清的硝基蓝四唑鎓水平降低。总之，PHSP _（（hp））和GLSP _（（hp））通过特异性和非特异性免疫力减轻了ETEC-K88诱导的腹泻的炎症反应。来自红藻的硫酸化多糖可用作缓解腹泻的功能性食品成分。

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