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首页> 外文期刊>RSC Advances >Improvement of high-glucose and insulin resistance of chromium malate in 3T3-L1 adipocytes by glucose uptake and insulin sensitivity signaling pathways and its mechanism
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Improvement of high-glucose and insulin resistance of chromium malate in 3T3-L1 adipocytes by glucose uptake and insulin sensitivity signaling pathways and its mechanism

机译：葡萄糖摄取和胰岛素敏感性信号通路改善3T3-L1脂肪细胞中苹果酸铬的高糖和胰岛素抵抗及其机制

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Previous study has revealed that chromium malate could improve insulin resistance and the regulation of fasting blood glucose in type 2 diabetic rats. This study was designed to investigate the effect of chromium malate on hypoglycemic and improve insulin resistance activities in 3T3-L1 adipocytes with insulin resistance and investigate the acting mechanism. The result indicated that chromium malate exhibited direct hypoglycemic activity in vitro . Compared with the model group, chromium malate could significantly promote the expression levels of GLUT-4, Akt, Irs-1, PPARγ, PI3K and p38-MAPK and their mRNA, increase p -AKT/AKT level, AKT and AMPKβ1 phosphorylation and reduce Irs-1 phosphorylation and p -Irs-1/Irs-1 level in 3T3-L1 adipocytes ( p < 0.05). Chromium malate is more effective in regulating the proteins and mRNA expressions than those of chromium trichloride and chromium picolinate. Compared to the model group, pretreatment with the specific p38-MAPK inhibitor completely inhibited the GLUT-4 and Irs-1 proteins and mRNA expressions induced by the chromium malate. In conclusion, chromium malate had a beneficial influence on improvement of controlling glucose levels and insulin resistance in 3T3-L1 adipocytes with insulin resistance by regulating proteins productions and genes expressions in glucose uptake and insulin sensitivity signaling pathways.
机译：先前的研究表明苹果酸铬可以改善2型糖尿病大鼠的胰岛素抵抗和空腹血糖的调节。本研究旨在研究苹果酸铬对降糖的影响，并通过胰岛素抵抗改善3T3-L1脂肪细胞的胰岛素抵抗活性，并研究其作用机理。结果表明，苹果酸铬在体外具有直接降糖活性。与模型组相比，苹果酸铬可显着促进GLUT-4，Akt，Irs-1，PPARγ，PI3K和p38-MAPK及其mRNA的表达水平，增加p -AKT / AKT水平，AKT和AMPKβ1磷酸化并降低3T3-L1脂肪细胞中的Irs-1磷酸化和p -Irs-1 / Irs-1水平（p <0.05）。苹果酸铬在调节蛋白质和mRNA表达方面比三氯化铬和吡啶甲酸铬更有效。与模型组相比，用特异的p38-MAPK抑制剂预处理可完全抑制苹果酸铬诱导的GLUT-4和Irs-1蛋白及mRNA表达。总之，苹果酸铬通过调节葡萄糖摄取和胰岛素敏感性信号传导途径中的蛋白质产生和基因表达，对改善具有胰岛素抵抗的3T3-L1脂肪细胞中控制葡萄糖水平和胰岛素抵抗具有有益的影响。

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